Dexmedetomidine Clinical Trials

52 recruitingLast updated: June 17, 2026

There are 52 actively recruiting dexmedetomidine clinical trials across 10 countries. Studies span Not Applicable, Phase 4, Phase 3, Phase 1. Top locations include Beijing, Beijing Municipality, China, Cairo, Egypt, Tanta, El-Gharbia, Egypt. Updated daily from ClinicalTrials.gov.


Dexmedetomidine Trials at a Glance

52 actively recruiting trials for dexmedetomidine are listed on ClinicalTrialsFinder across 6 cities in 10 countries. The largest study group is Not Applicable with 28 trials, with the heaviest enrollment activity in Beijing, Cairo, and Tanta. Lead sponsors running dexmedetomidine studies include Peking University First Hospital, Tanta University, and Beijing Tiantan Hospital.

Browse dexmedetomidine trials by phase

Treatments under study

About Dexmedetomidine Clinical Trials

Looking for clinical trials for Dexmedetomidine? There are currently 46 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Dexmedetomidine trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Dexmedetomidine clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 52 trials

Recruiting
Phase 4

Propofol-Only Versus Dexmedetomidine-Propofol in Children Undergoing Magnetic Resonance Imaging

DexmedetomidinePediatric SedationRecovery Time+3 more
Boston Children's Hospital105 enrolled1 locationNCT07369128
Recruiting
Phase 4

Dexmedetomidine vs Lignocaine for Reducing Intubation-Induced Hemodynamic Responses in Cardiac Surgery: A Randomized Controlled Trial

DexmedetomidineLignocaineLaryngoscopic Stress Response
Rawalpindi Institute of Cardiology70 enrolled1 locationNCT07611890
Recruiting
Not Applicable

Dexmedetomidine and Propofol for Sedation in Cataract Surgery.

Nausea and VomitingDexmedetomidineSedation+7 more
Saint-Joseph University1,000 enrolled1 locationNCT07556133
Recruiting
Phase 4

Intranasal Dexmedetomidine-esketamine Administration and Postoperative Pain in Pediatric Patients

Postoperative PainEsketamineDexmedetomidine+3 more
Peking University First Hospital160 enrolled1 locationNCT07479602
Recruiting
Phase 4

Impact of Perioperative Dexmedetomidine and Esketamine on Postoperative Quality of Recovery

Quality of recoverySurgeryEsketamine+2 more
Peking University First Hospital316 enrolled1 locationNCT07308756
Recruiting
Not Applicable

Effect of Intranasal Dexmedetomidine on the Incidence of Emergence Agitation in Children Undergoing Strabismus Surgery

Dexmedetomidineemergence agitation
Alexandria University120 enrolled1 locationNCT07523438
Recruiting
Not Applicable

Intrathecal Dexmedetomidine With Bupivacaine, in Patients Undergoing Knee Orthopedic Surgery

BupivacaineIntrathecal DexmedetomidineKnee Orthopedic Surgery
Cairo University120 enrolled1 locationNCT07522736
Recruiting
Phase 4

Comparison of Post Operative Analgesia in Patients Undergoing Lower Abdominal Surgeries Receiving Ultrasound Guided Block With Dexmetomidine vs Dexmethasone

DexmedetomidinePost Operative AnalgesiaTAP Block
Pakistan Institute of Medical Sciences60 enrolled1 locationNCT07508202
Recruiting
Not Applicable

Virtual Reality Versus Intravenous Dexmedetomidine on Maternal Anxiety, Stress, Hemodynamics, and Neonatal Outcomes During Cesarean Section

StressVirtual RealityDexmedetomidine+4 more
Benha University52 enrolled1 locationNCT07343843
Recruiting
Not Applicable

Oral Melatonin Versus Nebulized Dexmedetomidine on Emergence Agitation in Children Undergoing Adenotonsillectomy

Childrenadenotonsillectomyemergence agitation+2 more
Tanta University96 enrolled1 locationNCT07345715
Recruiting
Not Applicable

Intravenous Lidocaine Infusion Versus Intravenous Dexmedetomidine Infusion During Sleeve Gastrectomy

Bariatric SurgeryDexmedetomidineLidocaine
Alexandria University40 enrolled1 locationNCT07327905
Recruiting
Not Applicable

Comparison of the Hemodynamic Effects of Ketamine - Dexmedetomidine (Ketodex) Versus Propofol-ketamine Admixture (Ketofol) During Induction of Anesthesia in Elderly: A Randomized Comparative Study

Ketamine-dexmedetomidine Induction of Anesthesia
Kasr El Aini Hospital102 enrolled1 locationNCT07002073
Recruiting
Not Applicable

Intrathecal Dexmedetomidine-Fentanyl Combination Versus Fentanyl Alone as Adjuvant to Bupivacaine in Spinal Anesthesia for Above Knee Amputation in Sarcomas of Lower Extremity

DexmedetomidineSarcomasIntrathecal+5 more
National Cancer Institute, Egypt58 enrolled1 locationNCT07276867
Recruiting
Phase 4

Cognitive Outcomes After Dexmedetomidine Sedation in Cardiac Surgery Patients

ConfusionCognitive DysfunctionMolecular Mechanisms of Pharmacological Action+14 more
Sunnybrook Health Sciences Centre2,400 enrolled8 locationsNCT04289142
Recruiting
Phase 4

Determination of ED50 and ED95 With Clinical Efficacy of Intranasal Dexmedetomidine Combined With Esketamine for Preoperative Sedation in Pediatric General Anesthesia

EsketamineDexmedetomidinePreoperative Anxiety+5 more
Second Affiliated Hospital of Wenzhou Medical University80 enrolled2 locationsNCT06853431
Recruiting
Not Applicable

The Efficacy and Safety of Pregabalin Combined With Dexmedetomidine in Patients With Fibromyalgia

DexmedetomidineFibromyalgiaPregabalin
Beijing Tiantan Hospital400 enrolled1 locationNCT07230197
Recruiting
Phase 4

Sedation With Dexmedetomidine-esketamine Combination and Delirium in ICU Patients

Older PatientsEsketamineDexmedetomidine+3 more
Peking University First Hospital100 enrolled1 locationNCT07151716
Recruiting
Not Applicable

Transversalis Fascia Plane Block Versus Intrathecal Dexmedetomidine in Patients Undergoing Cesarean Section

Cesarean SectionTransversalis Fascia Plane BlockIntrathecal Dexmedetomidine
Tanta University50 enrolled1 locationNCT07170267
Recruiting
Not Applicable

Do Increasing Preoperative Timing of Single Dexmedetomidine Dose Have an Effect on Stress Response of Laryngoscopy and Intubation?

DexmedetomidineIntubationStress Response+2 more
Tanta University45 enrolled1 locationNCT07165483
Recruiting
Not Applicable

Intraoperative Infusion of Either Lidocaine or Dexmedetomidine on Regional Cerebral Oxygen Saturation and Postoperative Delirium in Elderly Patients Undergoing Abdominal Surgeries

Cerebral oxygen saturationDexmedetomidineElderly Patients+4 more
Tanta University100 enrolled1 locationNCT07108764