RecruitingNCT07332234

Optic Nerve Ultrasound for Assessing Cerebral Inflammation and Intracranial Hypertension in Cerebral Pathologies

Utility of Optic Nerve Ultrasonography in Assessing Cerebral Inflammation and Intracranial Hypertension in Patients With Cerebral Impairment

Sponsor

Spitalul Clinic de Boli Infecțioase și tropicale "Dr. Victor Babeș"

Enrollment

200 participants

Start Date

Dec 1, 2025

Study Type

OBSERVATIONAL

Conditions

Ultrasound Stroke Meningitis/Encephalitis Meningitis Intracranial Hypertension Cerebral Tumors

Summary

Timely detection of signs of raised intracranial pressure or persistent inflammation within the meninges can expedite therapeutic decisions improving the prognosis of patients with brain damage. Optic nerve ultrasonography provides a user-friendly, safe, low-cost, and non-invasive imaging method that can be easily deployed for ICU patient assessment. This study aims to evaluate the sensitivity and specificity of optic nerve ultrasound in estimating cerebral inflammation extension and cerebral edema in patients in the ICU. The working hypothesis is that optic nerve ultrasound is a useful tool in the rapid diagnosis of cerebral edema and the presence or persistence of cerebral inflammation, which can enable adapted and rapid therapeutic interventions.

Eligibility

Min Age: 18 YearsMax Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether ultrasound imaging of the optic nerve (the nerve behind the eye) can reliably detect brain swelling and increased pressure inside the skull in people admitted to hospital with suspected brain conditions. **You may be eligible if...** - You are between 18 and 60 years old - You have been admitted to hospital with suspected meningitis, encephalitis, stroke, or a brain tumor **You may NOT be eligible if...** - You are under 18 or over 60 years old - You have an eye condition that prevents the ultrasound from being performed (e.g., eye infection, corneal injury, glaucoma, or trauma) - You have a condition that prevents a lumbar puncture (e.g., bleeding disorder, spinal abscess, or local infection) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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