Optic Nerve Ultrasound for Assessing Cerebral Inflammation and Intracranial Hypertension in Cerebral Pathologies
Utility of Optic Nerve Ultrasonography in Assessing Cerebral Inflammation and Intracranial Hypertension in Patients With Cerebral Impairment
Spitalul Clinic de Boli Infecțioase și tropicale "Dr. Victor Babeș"
200 participants
Dec 1, 2025
OBSERVATIONAL
Conditions
Summary
Timely detection of signs of raised intracranial pressure or persistent inflammation within the meninges can expedite therapeutic decisions improving the prognosis of patients with brain damage. Optic nerve ultrasonography provides a user-friendly, safe, low-cost, and non-invasive imaging method that can be easily deployed for ICU patient assessment. This study aims to evaluate the sensitivity and specificity of optic nerve ultrasound in estimating cerebral inflammation extension and cerebral edema in patients in the ICU. The working hypothesis is that optic nerve ultrasound is a useful tool in the rapid diagnosis of cerebral edema and the presence or persistence of cerebral inflammation, which can enable adapted and rapid therapeutic interventions.
Eligibility
Inclusion Criteria3
- Patients admitted into one of the specified wards of the involved hospitals
- Patients aged 18-60 years
- Suspected meningitis, encephalitis, stroke or cerebral tumors
Exclusion Criteria3
- Age under 18 years or over 60 years old
- Ocular lesions preventing ocular ultrasound (palpebral infections, cornean erosions, glaucoma, trauma)
- Conditions preventing lumbar puncture (coagulation disorders, epidural abscesses, local infections)
Interventions
Ultrasonographic measurement of the optic nerve sheath diameter
Locations(2)
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NCT07332234