RecruitingPhase 1NCT07332260
Alzheimer's Disease and Faecal Microbiota Transplantation -a Pilot Study
Alzheimer's Disease and Faecal Microbiota Transplantation
Sponsor
University Hospital of North Norway
Enrollment
10 participants
Start Date
May 1, 2026
Study Type
INTERVENTIONAL
Conditions
Summary
The goal of this study is to assess the feasibility and safety of faecal microbiota transplantation for Alzheimer's disease.
Eligibility
Min Age: 18 Years
Inclusion Criteria3
- Alzheimer's dementia mild to moderate stage
- Presence of Alzheimer pathology core 1 biomarkers as defined by National Institute on Aging-Alzheimer's Association (NIA-AA) criteria (2024)
- Capable of giving informed consent
Exclusion Criteria17
- Contraindications for colonoscopy examination
- Contraindications for Magnetic Resonance Imaging (MRI)
- Life expectancy < 1 year
- Clinical frailty scale 7 or more
- History of seizure disorder
- History of brain tumour or intracranial bleed
- Major psychiatric disorder such as schizophrenia, bipolar disorder, or major depressive disorder
- Alcohol or substance abuse
- Decompensated heart disease
- Malignancy
- Current use of anticoagulant treatment (dual acting oral anticoagulant or warfarin)
- Pregnant or planning pregnancy
- Colonic adenomas over 1 cm, tumours or signs of active colitis on colonoscopy
- Status after colectomy or hemicolectomy
- Inflammatory bowel disease
- Immunocompromised individual
- Receiving biological/antibody treatment
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Interventions
BIOLOGICALBiological: Preprocessed thawed donor FMT
Biological: Preprocessed FMT solution is administered to the right side of the colon during a colonoscopy.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07332260
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