Desloratadine in Patients With Ulcerative Colitis

This study is testing whether desloratadine — a common allergy medication (antihistamine) — can help reduce inflammation and improve symptoms in patients with mild-to-moderate ulcerative colitis (an inflammatory bowel disease). **You may be eligible if...** - You are between 18 and 65 years old - You have been diagnosed with mild or moderate active ulcerative colitis - You are currently being treated with mesalamine (5-aminosalicylic acid) **You may NOT be eligible if...** - You have severe ulcerative colitis - You have significant liver or kidney problems - You are pregnant or breastfeeding - You are taking steroids, immunosuppressants, or biologic therapies for your colitis - You are allergic to desloratadine - You have had colon cancer or part of your colon removed Talk to your doctor to see if this trial is right for you.