RecruitingNCT07334210
The Characteristics of Gut Microbiota in Patients With Sarcopenia and the Development of Probiotics
Sponsor
Seoul National University Bundang Hospital
Enrollment
150 participants
Start Date
Jun 13, 2025
Study Type
OBSERVATIONAL
Conditions
Summary
The primary aim of this study is to identify the composition and characteristics of the gut microbiota in patients with sarcopenia in older adults, and compare these with the gut microbiota characteristics of older adults and young control groups to determine differences. Secondary purpose of this study is to provide data on the characteristics of gut microbiota for the development of probiotics effective in treating sarcopenia in older adults.
Eligibility
Min Age: 20 YearsMax Age: 90 Years
Inclusion Criteria19
- Sarcopenia patient group
- Individuals aged 65 to 90 years
- Meet the diagnostic criteria for sarcopenia based on the 2019 Asian Working Group for Sarcopenia (AWGS) guidelines:
- Low appendicular skeletal muscle mass
- DEXA: <7.0 kg/m² (men), <5.4 kg/m² (women)
- BIA: <7.0 kg/m² (men), <5.7 kg/m² (women)
- Low muscle strength
- Handgrip strength: <28 kg (men), <18 kg (women) or
- Low physical performance
- -meter walk speed <1.0 m/s
- -chair stand test ≥12 seconds
- Short Physical Performance Battery (SPPB) score ≤9
- Voluntarily agree to participate in the clinical study and sign the informed consent form
- Older adult control group
- Individuals aged 65 to 90 years
- Voluntarily agree to participate in the clinical study and sign the informed consent form
- Young adult control group
- Individuals aged 20 to 50 years
- Voluntarily agree to participate in the clinical study and sign the informed consent form
Exclusion Criteria9
- Individuals currently under treatment for severe diseases of the cardiovascular, immune, respiratory, gastrointestinal/hepatic and biliary, renal/urinary, neurological, psychiatric systems, infectious diseases, or malignant tumors (Exception: skin tumors other than melanoma are excluded; cancer survivors may participate if more than 5 years have passed since complete remission).
- Individuals who have difficulty performing independent activities of daily living due to musculoskeletal or neurological diseases, or cognitive impairment (e.g., those with spinal disorders requiring surgery or having walking limitations).
- Individuals who regularly consume alcohol according to WHO daily intake standards (≥ 40 g/day for men, ≥ 20 g/day for women).
- Heavy smokers (≥ 20 cigarettes/day).
- Individuals with AST (GOT) or ALT (GPT) levels ≥ 3 times the upper limit of normal established by the testing institution.
- Patients with uncontrolled hypertension (systolic blood pressure ≥ 140 mmHg or diastolic blood pressure ≥ 90 mmHg, measured after the subject has rested for 10 minutes).
- Patients with uncontrolled diabetes mellitus (HbA1c > 7.0%).
- Individuals with TSH ≤ 0.1 μIU/mL or ≥ 10 μIU/mL.
- Individuals deemed unsuitable for other reasons at the discretion of the investigator.
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Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07334210
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