RecruitingNot ApplicableNCT07334626

Impact of Pilates Exercises on Bone Mineral Density in Breast Cancer Survivors Receiving Hormonal Therapy


Sponsor

Benha University

Enrollment

60 participants

Start Date

Jan 1, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

Breast cancer survivors receiving endocrine (hormonal) therapy (aromatase inhibitors) are at high risk for cancer treatment-induced bone loss and osteoporosis due to estrogen depletion.


Eligibility

Sex: FEMALEMin Age: 40 YearsMax Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a 12-week Pilates exercise program can improve bone density in female breast cancer survivors who are taking hormonal therapy (aromatase inhibitors), which is known to weaken bones over time. **You may be eligible if...** - You are a female breast cancer survivor between 40 and 60 years old - You have confirmed Stage I–III breast cancer (by biopsy) - You have been taking aromatase inhibitor hormone therapy for at least 3 months - Your bone density is low (T-score ≤ –1.0 at spine or hip) - You are cleared for low-to-moderate exercise and can attend sessions three times per week for 12 weeks **You may NOT be eligible if...** - Your breast cancer has spread (Stage IV) or has come back - You have had a bone fracture from osteoporosis in the past year - You have severe heart, breathing, or joint conditions that prevent exercise - You have uncontrolled diabetes, high blood pressure, or thyroid problems - You are currently taking corticosteroids Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERPilates Exercises

The Pilates program will consist of mat-based exercises with optional use of light equipment such as resistance bands and small weights. Each session will last 60 minutes and will be performed three times per week over a total duration of 12 weeks. The program will follow a structured progression with systematic increases in exercise difficulty, load, and repetitions based on individual tolerance. The intervention will focus on enhancing core control, spinal extension and posture, lower-limb weight-bearing activities, and balance. Sessions will be initially supervised by a trained physiotherapist with expertise in oncology rehabilitation.

DRUGCalcium and Vitamin D Supplementation

Participants will receive daily oral calcium supplementation at a total dose of 1,200 mg/day, combined with vitamin D (total daily vitamin D dose: 200 IU), administered throughout the study period as part of standard osteoporosis management for breast cancer survivors receiving hormonal therapy.


Locations(1)

Outpatient clinic, faculty of Physical Therapy, Benha university

Banhā, Benha, Egypt

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NCT07334626


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