Evaluation of Intraoperative Contrast Enhanced Ultrasound for the Identification of Pituitary Adenoma in Cushing's Disease Compared to Other Pituitary Tumors

This study is evaluating whether a special intraoperative ultrasound technique (contrast-enhanced ultrasound) can help surgeons better identify and locate pituitary tumors during brain surgery for Cushing's disease, compared to other pituitary tumors. **You may be eligible if...** - You have been diagnosed with Cushing's disease (caused by a pituitary tumor producing excess cortisol) OR you need surgery for another pituitary tumor - You have agreed to undergo transsphenoidal surgery (through the nose to reach the pituitary gland) - Alternatively, you are undergoing any pituitary surgery with the designated study surgeons (for the non-contrast protocol) **You may NOT be eligible if...** - You are unable to give consent (or your legal guardian declines) - You are allergic to the contrast agent used (or its ingredients, such as polyethylene glycol or perflutren) - You are pregnant - You have a heart condition with abnormal blood flow direction (right-to-left or bidirectional cardiac shunt) Talk to your doctor to see if this trial is right for you.