RecruitingNot ApplicableNCT07341243

Exercising in Hot Conditions: How Does it Effect Blood Glucose in People With T1D

The Effect of Acute Heat Exposure on Glucose Use During Moderate-intensity Exercise in People With Type 1 Diabetes

Sponsor

Liverpool John Moores University

Enrollment

38 participants

Start Date

Nov 1, 2025

Study Type

INTERVENTIONAL

Conditions

Type 1 Diabetes (T1D)

Summary

A randomised, crossover, counterbalanced repeated measures study will be conducted to examine the effect of acute heat exposure on rate of change in blood glucose concentration during 40 minutes of moderate-intensity exercise and for 30 minutes after exercise. Participants will complete two experimental conditions during two separate laboratory visits, with the order of conditions randomised. One condition will be a temperate condition of 20°C with 50% relative humidity (Temperate), the other will be 40°C with 50% relative humidity (Heat). Visits will be identical, including time of day, except for the condition. Visits will be separated by 24h. Testing will take place in the laboratories of the Research Institute for Sport and Exercise Sciences at Liverpool John Moores University.

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Inclusion Criteria5

T1D diagnosis more than 1 years ago (to ensure participants are out of the honeymoon period)
Using insulin therapy with multiple daily injections (MDI), insulin pump (pump), or hybrid closed-loop (HCL)
o If using a HCL system have experience of using a pre-programmed basal rate in manual mode during exercise
Aged 18-65 years
Regularly engaged in endurance exercise (training at least twice per week for ≥30 minutes per session)

Exclusion Criteria11

Pregnancy
\<6 months postpartum or stopped breastfeeding \<1 month before recruitment
Existing cerebrovascular or cardiovascular disease
Significant history of hyperglycaemia (HbA1c \>85 mmol/mol)
History of severe hypoglycaemia requiring third party assistance within the last 3 months
Body weight \<36.5kg
Difficulty swallowing tablets
Appointment for an MRI test that cannot be rescheduled
Obstructive gastrointestinal disease
History of gastrointestinal surgery
Have an implanted medical device