Steroid Use in Treatment of Allergic Reactions to Food
Evaluation of Emergency Medication in Children With Food Allergies: a Prospective, Randomized Clinical Multicenter Study Comparing Antihistamines Versus Antihistamines Plus Steroids in a Controlled Setting of Oral Food Challenges in Children.
Johannes Trueck
160 participants
Jan 26, 2026
INTERVENTIONAL
Conditions
Summary
In this study, the investigators want to find out whether a specific medication commonly used for severe allergic reactions is really necessary. When children have allergic reactions to foods, they are often given medications to relieve the symptoms. In addition to adrenaline and antihistamines, steroids are frequently administered in German-speaking Switzerland. However, it is unclear whether steroids are really helpful in this situation. To investigate this, the investigators are comparing two groups: one group receives additional steroids, and the other does not. Which treatment a participant receives is decided randomly, like flipping a coin. The study takes place during a pre-scheduled provocation test at the clinic. If an allergic reaction occurs, the usual emergency medications will be administered. Doctors will closely monitor how the reaction develops. No additional tests or visits are required. The results of this study could help improve allergy treatment in the future.
Eligibility
Inclusion Criteria1
- suspected or confirmed IgE-mediated food allergy
Exclusion Criteria4
- Non-IgE mediated food allergies
- Non-food allergies
- Age outside the specified range
- Contraindications for an oral food challenge or oral steroid use within one week before the challenge.
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Interventions
Oral administration of antihistamines for treatment of allergic symptoms during the oral food challenge.
Oral administration of systemic corticosteroids as adjunctive treatment of allergic reactions during the oral food challenge.
Intramuscular administration of adrenaline as rescue treatment for severe allergic reactions (anaphylaxis), administered as clinically indicated.
Locations(2)
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NCT07341776