RecruitingPhase 4NCT07341776

Steroid Use in Treatment of Allergic Reactions to Food

Evaluation of Emergency Medication in Children With Food Allergies: a Prospective, Randomized Clinical Multicenter Study Comparing Antihistamines Versus Antihistamines Plus Steroids in a Controlled Setting of Oral Food Challenges in Children.


Sponsor

Johannes Trueck

Enrollment

160 participants

Start Date

Jan 26, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

In this study, the investigators want to find out whether a specific medication commonly used for severe allergic reactions is really necessary. When children have allergic reactions to foods, they are often given medications to relieve the symptoms. In addition to adrenaline and antihistamines, steroids are frequently administered in German-speaking Switzerland. However, it is unclear whether steroids are really helpful in this situation. To investigate this, the investigators are comparing two groups: one group receives additional steroids, and the other does not. Which treatment a participant receives is decided randomly, like flipping a coin. The study takes place during a pre-scheduled provocation test at the clinic. If an allergic reaction occurs, the usual emergency medications will be administered. Doctors will closely monitor how the reaction develops. No additional tests or visits are required. The results of this study could help improve allergy treatment in the future.


Eligibility

Min Age: 6 MonthsMax Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Adrenaline (rescue medication), a drug called Antihistamines, and others for people with allergy in children, anaphylactic reaction, and other related conditions. The study is currently recruiting participants at 2 locations. People eligible for this study include aged 6 Months to 18 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGAntihistamines

Oral administration of antihistamines for treatment of allergic symptoms during the oral food challenge.

DRUGSystemic corticosteroids

Oral administration of systemic corticosteroids as adjunctive treatment of allergic reactions during the oral food challenge.

DRUGAdrenaline (rescue medication)

Intramuscular administration of adrenaline as rescue treatment for severe allergic reactions (anaphylaxis), administered as clinically indicated.


Locations(2)

University Children's Hospital Basel

Basel, Basel, Switzerland

University Children's Hospital, Zürich

Zurich, Canton of Zurich, Switzerland

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT07341776


Related Trials