A Prospective, Safety, and Efficacy Clinical Trial of Pressurized Intraperitoneal Aerosol Therapy for Peritoneal Metastasis of Colorectal Cancer

This study is testing a treatment called pressurized intraperitoneal aerosol chemotherapy (PIPAC) — where chemotherapy drugs are delivered as a fine mist directly into the abdomen during a keyhole surgery — for people with colorectal cancer that has spread to the lining of the abdominal cavity (peritoneal metastasis). **You may be eligible if...** - You are 18–75 years old - You have colorectal cancer that has spread to the peritoneum (lining of the abdomen), confirmed by biopsy, with no spread elsewhere - Your expected survival is more than 6 months - Your organs are functioning at acceptable levels - You are able to undergo laparoscopic (keyhole) surgery **You may NOT be eligible if...** - You have a bowel obstruction or blockage - You rely entirely on IV nutrition - You have severe abdominal infection or extensive abdominal scarring - You have portal vein blood clots or severe heart or lung conditions - You are pregnant or breastfeeding - You have a significant psychiatric history - You have been in another clinical trial within the past 3 months Talk to your doctor to see if this trial is right for you.