RecruitingNot ApplicableNCT07351032

Understanding How Movements Are Transferred From Task to Task in Parkinson's Disease

Neural Mechanism of Skill Transfer in Parkinson's Disease


Sponsor

McGill University

Enrollment

24 participants

Start Date

Nov 18, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to understand how a specific brain area, the Posterior Parietal Cortex (PPC), plays a role in movement transfer from walking on a split-belt treadmill (SBT) to walking on the ground in people with Parkinson's disease (PwPD). Here, investigators will apply repeated transcranial magnetic stimulation (rTMS) to upregulate the PPC. Then, the differences in the gait parameters between pre- and post-interventions will be compared between the TMS-active and the TMS-sham.


Eligibility

Min Age: 50 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at how people with Parkinson's disease learn and transfer movement skills from one activity to another — for example, whether practicing walking on a special treadmill can help with everyday movement. Researchers want to understand if motor learning generalizes across different tasks. **You may be eligible if:** - You have been diagnosed with Parkinson's disease - You do not experience "freezing" (sudden inability to move) while walking - You can walk independently for 30 minutes without a cane or walker - You have no other neurological conditions - You have not previously used a split-belt treadmill - You have no significant balance, muscle, or joint problems - Your memory and thinking are intact (score of 25 or higher on a standard test) **You may NOT be eligible if:** - You have severe uncontrolled movements (dyskinesia) that affect your balance or walking - You are unable to walk safely on a treadmill - You have a deep brain stimulator implant - You have vision or hearing impairment - You have another neurological condition besides Parkinson's Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

OTHERTranscranial Magnetic Stimulation Active

ACTIVE: intermittent Theta Burst Stimulation (a patterned form of rTMS). The participants will receive iTBS (50hz bursts at 5Hz for 600 pulses for a total duration of 3-minutes) over the right PPC at 80% RMT of the FDI.

OTHERTranscranial Magnetic Stimulation Sham

SHAM: 2 coils on top of each other will be used instead of 1. The coil furthest to the head will be reversed. The coil on the head will not be stimulating but the reversed coil will (current directed away from the brain) with stimulate with the same parameters at the active stimulation (intermittent Theta Burst Stimulation (a patterned form of rTMS). The participants will receive iTBS (50hz bursts at 5Hz for 600 pulses for a total duration of 3-minutes) over the right PPC at 80% RMT of the FDI.


Locations(1)

McGill University - Currie Gymnasium

Montreal, Quebec, Canada

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT07351032


Related Trials