T Cell Lymphoma -Stratified Therapy After Response to First-line Treatment-CR

This study is testing a treatment strategy for people with a type of aggressive blood cancer called peripheral T-cell lymphoma (PTCL) who have achieved a complete remission (no detectable cancer) after their first round of chemotherapy. Researchers want to find the best next step — such as stem cell transplant or observation — to prevent the cancer from coming back. **You may be eligible if:** - You are aged 18 to 70 - You have been diagnosed with PTCL, ALK-negative ALCL, or PTCL with a TFH phenotype — confirmed by a central lab - You achieved a complete response (cancer completely cleared) after first-line chemotherapy (CHOP or similar) - Your heart, liver, and kidney function are adequate - Your heart pumping function (ejection fraction) is 50% or higher - Your general health is good (ECOG performance status 0 or 1) **You may NOT be eligible if:** - Your cancer is at stage I only - You have had another cancer in the past 5 years (with some exceptions) - You have active infections including HIV, active tuberculosis, or active hepatitis B or C - You have serious heart problems (e.g., heart failure, recent heart attack, severe arrhythmia) - You are pregnant or breastfeeding - You have a psychiatric condition preventing informed consent Talk to your doctor to see if this trial is right for you.