Single-site Pilot Study Evaluating the Effect of QLS-111 Ophthalmic Solution on Posterior Perfusion and Vessel Dilation

This small pilot study is testing an experimental eye drop called QLS-111 to see whether it improves blood flow and widens blood vessels at the back of the eye. It is being studied in people with open-angle glaucoma, normal-tension glaucoma, or stable diabetic eye disease, where reduced blood flow may contribute to vision problems. **You may be eligible if:** - You have a diagnosis of mild to moderate open-angle glaucoma, normal-tension glaucoma, or stable non-proliferative diabetic retinopathy in at least one eye - Your vision is at least 20/200 (corrected) in each eye - You are willing and able to follow study instructions **You may NOT be eligible if:** - You have other active eye diseases beyond those listed above - You are using more than one eye pressure-lowering medication - You have used certain eye drop beta-blockers (such as timolol) within the past 3 months - You have serious retinal disease likely to need treatment during the study - You have received anti-VEGF injections or steroid eye treatments in the past 3 months - You have significant kidney, liver, heart, or lung disease - You use calcium channel blockers - You have poorly controlled blood pressure Talk to your doctor to see if this trial is right for you.