Comparison Between Two Instrumentation Techniques on Postoperative Pain and Level of Neuropeptides
Impact Of Manual-Less Root Canal Instrumentation Versus Conventional Rotary Instrumentation On Post Operative Pain And Level Of Neuropeptides: Randomized Controlled Clinical Trial
Alexandria University
34 participants
Sep 1, 2025
INTERVENTIONAL
Conditions
Summary
General aim: assessment of post operative pain and time of preparation with the execution of manual-less technique and conventional technique. Specific aim: correlation between post operative pain and release of Substance P and Calcitonin gene-related peptide.
Eligibility
Inclusion Criteria6
- Patients with symptomatic irreversible pulpitis and apical periodontitis in mandibular molars with closed apex.(17)
- Healthy males and females (Category: American Society of Anesthesiologists class I).
- Age of patients range from 18 to 50 years old.
- Those who could understand the use of the numeric rating scale (NRS) for pain.
- In cases where radiographs show no root resorption or abnormal anatomy.
- Patients with good oral hygiene and free from periodontal diseases.
Exclusion Criteria5
- Allergy to anesthetics.
- Pregnancy
- Unrestorable teeth.
- Patient on analgesics.
- Prescence of root resorption or abnormal anatomy.
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Interventions
Canals preparation with rotary dota files escaping scouting and glide path step
Canal preparation with rotary drill files, with prior scouting and glide path with hand files.
Locations(1)
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NCT07357233