RecruitingNCT07358572

Eye-Brain-Kidney in CKD

A Study on the Eye-Brain-Kidney Interaction Mechanisms in Chronic Kidney Disease Based on Multimodal Magnetic Resonance Imaging

Sponsor

Beijing Friendship Hospital

Enrollment

1,500 participants

Start Date

Dec 1, 2025

Study Type

OBSERVATIONAL

Conditions

Chronic Kidney Diseases

Summary

The goal of this observational study is to learn about the interaction between the eyes, brain, and kidneys in adult patients with Chronic Kidney Disease (CKD). The main question it aims to answer is: Do changes in the brain's network connectivity and the retina's blood vessels correlate with cognitive decline and kidney function in CKD patients? Participants with CKD who are already undergoing clinical care will complete cognitive tests and questionnaires, have non-invasive MRI scans of their brain and kidneys, and undergo non-invasive eye imaging (OCT/OCTA) of their retinas.

Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study examines how chronic kidney disease (CKD) affects the eyes and brain by looking at the retina (the back of the eye), brain blood flow, and kidney function together in the same patients. **You may be eligible if...** - You are between 18 and 70 years old - You have been diagnosed with chronic kidney disease (any stage from 1 to 5) - You are able to undergo an MRI scan without issues **You may NOT be eligible if...** - You have had a brain bleed or stroke - You have epilepsy or a psychiatric disorder - You are claustrophobic (afraid of enclosed spaces) - You are pregnant or breastfeeding - You have other brain or nervous system conditions such as a tumor or serious injury - You have severe heart failure or a recent heart attack - You have a pacemaker, cochlear implant, or certain metal implants that are not MRI-safe Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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