RecruitingNCT07358572

Eye-Brain-Kidney in CKD

A Study on the Eye-Brain-Kidney Interaction Mechanisms in Chronic Kidney Disease Based on Multimodal Magnetic Resonance Imaging

Sponsor

Beijing Friendship Hospital

Enrollment

1,500 participants

Start Date

Dec 1, 2025

Study Type

OBSERVATIONAL

Conditions

Chronic Kidney Diseases

Summary

The goal of this observational study is to learn about the interaction between the eyes, brain, and kidneys in adult patients with Chronic Kidney Disease (CKD). The main question it aims to answer is: Do changes in the brain's network connectivity and the retina's blood vessels correlate with cognitive decline and kidney function in CKD patients? Participants with CKD who are already undergoing clinical care will complete cognitive tests and questionnaires, have non-invasive MRI scans of their brain and kidneys, and undergo non-invasive eye imaging (OCT/OCTA) of their retinas.

Eligibility

Min Age: 18 YearsMax Age: 70 Years

Inclusion Criteria3

Aged 18-70 years.
Patients clinically diagnosed with CKD stages 1-5.
No contraindications for MRI examination (e.g., cardiac pacemaker, claustrophobia, cochlear implant, hearing aid, coronary stents implanted before 2015) and able to complete the MRI scan.

Exclusion Criteria7

Patients with recent or prior cerebral hemorrhage or cerebral infarction.
History of epileptic seizures or psychiatric disorders.
Patients with claustrophobia.
Pregnant or lactating patients.
Presence of other central nervous system diseases (e.g., tumor, trauma).
Unstable angina, congestive heart failure (NYHA class III or IV), or acute myocardial infarction.
Any systemic or other diseases deemed unsuitable for clinical trial participation.