Liquid Biopsy-Based Pre-Screening to Streamline LDCT Lung Cancer Screening in High-Risk Individuals

This study tests whether a liquid biopsy blood test (which looks for cancer DNA in the bloodstream) can help identify who truly needs a low-dose CT lung scan, potentially making lung cancer screening smarter and more targeted. **You may be eligible if...** - You are a current or former smoker (quit within 15 years), aged 55–74, with at least a 30 pack-year smoking history, OR - You are a non-smoker aged 55–75 with a parent, sibling, or child who has had lung cancer, OR - You are 21 or older and have been diagnosed with early-stage (I–II) or advanced-stage (III–IV) lung cancer and have not yet started treatment **You may NOT be eligible if...** - You are pregnant or breastfeeding - You have had a CT lung scan within the past 12 months (for high-risk individuals only) - You have a known allergy to CT contrast dye - You have already received treatment for lung cancer (for the cancer patient groups) Talk to your doctor to see if this trial is right for you.