RecruitingNCT07360925

Pericoronary Adipocyte Size Gradient

Direct Measurement of Pericoronary Adipocyte Size Gradient as a Parameter of Immunometabolic Changes of Perivascular Adipose Tissue


Sponsor

Institute for Clinical and Experimental Medicine

Enrollment

60 participants

Start Date

Jun 1, 2023

Study Type

OBSERVATIONAL

Conditions

Summary

Evaluation of pericoronary adipocyte gradient (PCAT) in relationship with local atherosclerotic changes in a patient undergoing heart transplantation.


Eligibility

Min Age: 30 YearsMax Age: 90 Years

Plain Language Summary

Simplified for easier understanding

This study examines fat tissue around the heart's coronary arteries in people undergoing heart transplants, to better understand how fat cell size relates to heart disease type — specifically dilated versus ischemic cardiomyopathy. **You may be eligible if...** - You are between 30 and 90 years old - You have been diagnosed with dilated cardiomyopathy (an enlarged, weakened heart) or ischemic cardiomyopathy (heart muscle damage from blocked arteries) - You are undergoing a heart transplant at the IKEM hospital **You may NOT be eligible if...** - You have a combined diagnosis of both dilated and ischemic cardiomyopathy - You have arrhythmogenic cardiomyopathy (a different type of heart muscle disease) - You have congenital heart defects (heart problems present from birth) - You have not provided informed consent Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREHeart transplantation for the final stage of heart failure

The study population comprises patients who underwent heart transplantation for heart failure at the Institute for Clinical and Experimental Medicine, Cardiovascular Surgery Department, between June 2023 and December 2028. Only the subjects' retrospective clinical data and matching heart samples will be analyzed.


Locations(1)

Centre of Experimental Medicine, Institute for Clinical and Experimental Medicine,

Prague, Czechia

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NCT07360925


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