RecruitingNCT07360925

Pericoronary Adipocyte Size Gradient

Direct Measurement of Pericoronary Adipocyte Size Gradient as a Parameter of Immunometabolic Changes of Perivascular Adipose Tissue


Sponsor

Institute for Clinical and Experimental Medicine

Enrollment

60 participants

Start Date

Jun 1, 2023

Study Type

OBSERVATIONAL

Conditions

Summary

Evaluation of pericoronary adipocyte gradient (PCAT) in relationship with local atherosclerotic changes in a patient undergoing heart transplantation.


Eligibility

Min Age: 30 YearsMax Age: 90 Years

Inclusion Criteria3

  • Age 30-90 years
  • Diagnosis of dilatational or ischemic cardiomyopathy
  • Patients undergoing heart transplantation in IKEM

Exclusion Criteria4

  • Known combined diagnosis of dilatational and ischemic cardiomyopathy
  • Arrhythmogenic cardiomyopathy
  • Congenital heart defects
  • Non-eligibility due to the absence of informed consent

Interventions

PROCEDUREHeart transplantation for the final stage of heart failure

The study population comprises patients who underwent heart transplantation for heart failure at the Institute for Clinical and Experimental Medicine, Cardiovascular Surgery Department, between June 2023 and December 2028. Only the subjects' retrospective clinical data and matching heart samples will be analyzed.


Locations(1)

Centre of Experimental Medicine, Institute for Clinical and Experimental Medicine,

Prague, Czechia

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NCT07360925


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