RecruitingNot ApplicableNCT07363421

TMS-Induced LH Response in Healthy Women in Luteal Phase

Feasibility Study Protocol: TMS-Induced LH Response in Healthy Women in the Luteal Phase


Sponsor

The City College of New York

Enrollment

10 participants

Start Date

Feb 24, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this research is to establish whether non-invasive Transcranial Magnetic Stimulation (TMS), can affect modulation of hormones such: Luteinizing Hormone (LH) and Follicle-stimulating hormone (FSH). The hypothesis is that applying TMS to the Dorsolateral Prefrontal Cortex with specific pulse patterns, mimicking endogenous Gonodotropin-Releasing Hormone (GnRH) pulses that are known to stimulate LH secretion may modulate hormonal levels.


Eligibility

Sex: FEMALEMin Age: 22 YearsMax Age: 40 Years

Inclusion Criteria2

  • Healthy women aged 22-40 years with regular menstrual cycle.
  • In luteal phase at the time of visit.

Exclusion Criteria16

  • Presence of any known structural brain abnormalities or tumors.
  • Presence of metal implants/devices in the head or neck.
  • Has ever had a stroke, seizure, or has a family history of epilepsy.
  • Head injury with loss of consciousness.
  • Use of hormonal contraceptives in the past 3 months.
  • Irregular menstrual cycles.
  • Diagnosed with a reproductive system disorder (e.g., PCOS, endometriosis, infertility, hypogonadism).
  • History of endocrine disorders such diabetes mellitus, thyroid disease, adrenal disorders, pituitary tumor or others.
  • Been diagnosed or received treatment for depression, anxiety disorder, schizophrenia, PTSD or bipolar disorder.
  • Have a history of medical disorder such liver or renal impairment, HIV/AIDS or unstable cardiac disease.
  • Taking any medications that affect the central nervous system such as antidepressents, antipsychotics, GLP-1 receptor agonists or hormone therapies.
  • Are you pregnant, planning pregnancy or breastfeeding.
  • Have experienced difficulties in the past during blood draws such as locating the vein, fainting or other adverse reactions.
  • Have any sleep disorder such as insomnia or sleep apnea.
  • Have fear of needles or the sight of blood.
  • Underwent TMS stimulation in the past and had difficulties.

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Interventions

DEVICETranscranial Magnetic Stimulation Active

Participants will receive stimulation to the left DLPFC. Stimulation intensity will be standardized based on resting motor threshold. Stimulation will be delivered using NeuroStar system.

DEVICETranscranial Magnetic Stimulation Sham

Participants will undergo identical procedure to the active TMS group, including coil placement, session duration, and acoustic and somatic sensations. A sham device setting will be used that mimics the sound but does not deliver an effective magnetic field to the DLPFC.


Locations(1)

Site 1

New York, New York, United States

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NCT07363421


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