RecruitingNot ApplicableNCT07439458

Tumour Cell Response to Acute Aerobic Exercise in Breast Cancer Survivors: Modulatory Effects of Exercise Type and Intensity

Tumour Cell Response to Acute Aerobic Exercise in Breast Cancer Survivors: Modulatory Effects of Exercise Type and Intensity (TCReX) No: RSU/LSPA-PA-2024/1-0004 is Financed by the Investment of the European Union Recovery and Resilience Facility and the State Budget Within the Project "RSU Internal and RSU With LASE External Consolidation" No. 5.2.1.1.i.0/2/24/I/CFLA/005.

Sponsor

Riga Stradins University

Enrollment

40 participants

Start Date

Apr 1, 2024

Study Type

INTERVENTIONAL

Conditions

Breast Cancer Survivors Acute Exercise Breast Cancer Cell Lines Healthy Women Myokine Response

Summary

Cancer has emerged as a prominent cause of mortality in the 21st century, with breast cancer (BC) being the most diagnosed malignancy. Multidisciplinary cancer management has improved survival chances, but side effects and long-term consequences of treatments have significant implications for cancer survivors' health-related quality of life. Exercise is increasingly considered and used in cancer treatment and follow-up. However, studies demonstrating the biological mechanisms underlying the anticarcinogenic effects (ACE) of exercise are insufficient to justify the most appropriate physical activity for different clinical scenarios. Achieving scientific excellence in understanding the ACE of exercise in cancer management is critical to optimize treatment and enhance patients' quality of life.

Eligibility

Sex: FEMALEMin Age: 35 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating how a single bout of aerobic exercise affects cancer cells in the blood of breast cancer survivors. Researchers are comparing different types and intensities of exercise to understand which may best activate the immune system against cancer. There is also a healthy control group for comparison. **You may be eligible if... (breast cancer group)** - You are premenopausal (still having periods) - You have been diagnosed with Stage II or III triple-negative breast cancer (a type that does not respond to hormone therapies) - You completed surgery, chemotherapy, radiation, and/or immunotherapy 3 to 9 months ago - A cardiologist has cleared you for exercise testing **You may be eligible if... (healthy control group)** - You are premenopausal with no history of cancer - You are a similar age and fitness level to the breast cancer participants **You may NOT be eligible if...** - You are pregnant - You have an autoimmune disease, diabetes, or a metabolic disorder - You have cardiovascular disease - You have a condition that makes physical activity unsafe (e.g., asthma, severe anemia, spinal problems) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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