RecruitingNot ApplicableNCT07367412

Zinc Supplementation and Infections in Older Medical Patients

Effect of Zinc Supplementation on Occurrence of Infections in Older Medical Patients (ZOOM) - a Cluster Randomized Controlled Trial (ZOOM OUT).

Sponsor

Herlev Hospital

Enrollment

8,000 participants

Start Date

Feb 1, 2026

Study Type

INTERVENTIONAL

Conditions

Older Adults (65 Years and Older)Medical Patients in the Emergency Department

Summary

The goal of this clinical trial is to learn about the effect of zinc supplementation once daily for 12 months in older acute medical patients. The main question it aims to answer is: • Can daily zinc supplementation for 12 months increase Days Alive and Out of Hospital (DAOH)? Researchers will compare zinc supplementation to a control group, a group who do not receive zinc supplementation, to see if zinc supplementation can increase Days Alive and Out of Hospital, reduce antibiotic use, readmissions and mortality. Participants will take 22 mg zinc supplementation once daily for 12 months or not. The researchers will draw data on readmissions, antibiotic use and mortality during the 12 months follow-up period.

Eligibility

Min Age: 65 Years

Inclusion Criteria1

All medical patients aged ≥ 65 years assessed at the Medical Emergency Department, Herlev Hospital

Exclusion Criteria6

Self-supplementing with zinc at time of assessment (> 10 mg zinc/day)
Terminal illness (life expectancy < 6 months, estimated by Clinical Frailty Scale ≥8)
Patients receiving parenteral nutrition (partial or complete)
Patients treated with hemodialysis or peritoneal dialysis
Patients know with known severe dementia
Patients who do not understand Danish and patients with temporary civil person registration numbers (CPR)

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