RecruitingNCT07369414

Environmental Reservoirs of Non-tuberculous Mycobacteria in Cystic Fibrosis Households: A Case-control Study of Exposure Risk at Home

Sponsor

Research Center Borstel

Enrollment

120 participants

Start Date

Jan 1, 2026

Study Type

OBSERVATIONAL

Conditions

non-tuberculous mycobacteria Cystic Fibrosis (CF)Mucoviscidosis Mycobacterium Abscessus Infection

Summary

This multicenter, non-interventional case-control study investigates whether household environmental reservoirs, particularly water systems, are associated with non-tuberculous mycobacterial (NTM) infections in people with cystic fibrosis. Environmental samples from the homes of CF patients with and without NTM infection will be analyzed and genetically compared with available clinical isolates, alongside assessment of environmental risk factors, to improve understanding of exposure pathways and inform future prevention strategies.

Eligibility

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying Multi-modal NTM diagnostic including PCR, WGS, culture for people with cystic fibrosis (cf), mucoviscidosis, and other related conditions. The study is currently recruiting participants at 2 locations.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERMulti-modal NTM diagnostic including PCR, WGS, culture

Environmental samples from participants' households (e.g., water, dust, and soil) will be collected and tested for the presence of NTM. Analyses will be performed using PCR, culture-based methods, whole-genome sequencing (WGS), and subsequent bioinformatic analyses. In addition, available clinical NTM isolates from previous or future routine diagnostics will be included. If genomic sequencing has not yet been performed for these isolates, retrospective molecular genetic analysis (e.g., by WGS) will be conducted within the study to enable comparison with environmental isolates.