RecruitingNot ApplicableNCT07370402

The Analgesic Efficacy and Safety of Flurbiprofen Patch in Patients With Herpes Zoster

The Analgesic Efficacy and Safety of Topical Patches (Flurbiprofen Patch) in Patients With Herpes Zoster


Sponsor

Beijing Tiantan Hospital

Enrollment

750 participants

Start Date

Dec 15, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

Herpes zoster (HZ) is characterized by a painful dermatomal rash and significantly affects quality of life, with acute pain increasing the risk of postherpetic neuralgia. Although early antiviral therapy limits viral replication, its analgesic effect is insufficient, and many patients experience inadequate relief despite stepwise use of non-opioids and opioids. Topical NSAIDs offer a promising alternative by delivering localized analgesia with reduced systemic exposure. Therefore, investigators hypothesize that flurbiprofen patch may effectively reduce the severity of HZ pain without significantly increasing adverse events.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a flurbiprofen skin patch (an anti-inflammatory pain reliever applied to the skin) can safely and effectively reduce the pain caused by shingles (herpes zoster). **You may be eligible if...** - You are over 18 years old - You developed a shingles rash within the last 90 days - You have moderate to severe pain (rated at least 4 out of 10 on a pain scale) - Your liver and kidney function are within acceptable ranges - You are able to understand and complete study requirements **You may NOT be eligible if...** - You have previously used a flurbiprofen patch - Your shingles has spread widely across your body or affected your eyes - You have an allergy or intolerance to any component of the flurbiprofen patch - You have an immune disease, have had an organ transplant, or have cancer - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This is a simplified summary. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGFlurbiprofen patch combined with conventional therapy group

In the flurbiprofen patch combined with conventional therapy group, apply the patch to the painful point near the herpes lesion. Use one patch per day, twice a day. In addition, the group will contain conventional treatment for HZ, except flurbiprofen patch, including opioids, antiviral drugs and so on.

DRUGConventional therapy group

In the conventional therapy group, treatments will include opioids, antiviral drugs and so on.


Locations(1)

Beijing Tiantan Hospital, Beijing, Beijing 100070

Beijing, China

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NCT07370402


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