Minimal Effective Volume 90% for Double-injection Costoclavicular Block
Minimum Effective Volume of Lidocaine for Double-Injection Ultrasound-Guided Costoclavicular Block
McGill University Health Centre/Research Institute of the McGill University Health Centre
60 participants
Jun 16, 2026
INTERVENTIONAL
Conditions
Summary
In 2020, a trial demonstrated that a 2-injection technique constitutes the optimal method for the costoclavicular block. This study aims to determine the minimum amount of medication required to achieve a successful double-injection costoclavicular nerve. Block dose assignment will be done using an up-and-down sequential method, called the Biased Coin Design (BCD). The double-injection technique for US-guided costoclavicular block consists in depositing two thirds of the LA volume in the deep compartment (to anesthetize the posterior and medial cords), and one third of the injectate in the superficial compartment (to anesthetize the lateral cord). The ED90 will be calculated using isotonic regression with a 95% confidence interval derived by bootstrapping.
Eligibility
Inclusion Criteria3
- Age between 18 and 70 years
- American Society of Anesthesiologists classification 1-3
- Body mass index between 20 and 30
Exclusion Criteria9
- Adults who are unable to give their own consent
- Pre-existing neuropathy (assessed by history and physical examination)
- Coagulopathy (assessed by history and physical examination and, if deemed clinically necessary, by blood work up i.e. platelets≤ 100, International Normalized Ratio≥ 1.4 or partial prothrombin time ≥ 50)
- Renal failure (assessed by history and physical examination and, if deemed clinically necessary, by blood work up i.e. creatinine≥ 100)
- Hepatic failure (assessed by history and physical examination and, if deemed clinically necessary, by blood work up i.e. transaminases≥ 100)
- Allergy to LA
- Pregnancy
- Prior surgery in the infraclavicular region
- Chronic pain syndromes requiring opioid intake at home
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
ultrasound-guided double-injection costoclavicular nerve block with the same volume used in the previous successful block
Ultrasound-guided double-injection costoclavicular nerve block with lower volume than the previous successful block
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07374952