RecruitingNot ApplicableNCT07375667

Dynamic Airway Resistance & ML: Guide Sputum Suction in Ventilated Patients

Mechanisms of Dynamic Airway Resistance Monitoring and Machine Learning for Assessing Pulmonary Inflammation and Guiding Sputum Suction in Mechanically Ventilated Patients

Sponsor

Affiliated Hospital of Nantong University

Enrollment

258 participants

Start Date

Oct 30, 2025

Study Type

INTERVENTIONAL

Conditions

Ventilator-Associated Pneumonia (VAP)Mechanical Ventilation Pressure High Respiratory Depression Neonatal

Summary

Research has shown that timely suctioning not only improves survival rates but also enhances the quality of life in ventilator-dependent patients. However, clinical judgment on the optimal timing for suctioning currently relies primarily on physician experience, lacking scientific evidence \[10\]. Airway viscous resistance reflects the frictional resistance encountered by gas flow within the airways and is closely associated with airway patency. When airway secretions increase, viscous resistance undergoes dynamic changes. Therefore, analyzing these dynamic variations in viscous resistance derived from ventilator waveforms to determine the optimal suctioning timing and assess its clinical impact on the progression of pulmonary inflammation holds significant scientific value and offers new insights and methodologies for clinical practice.

Eligibility

Min Age: 18 YearsMax Age: 90 Years

Plain Language Summary

Simplified for easier understanding

This study uses machine learning (computer analysis) to track airway resistance patterns in patients on breathing machines (ventilators), with the goal of knowing the best time to suction mucus from the airway — improving care for critically ill patients. **You may be eligible if...** - You are on a ventilator and have been diagnosed with acute respiratory distress syndrome (ARDS), a severe lung condition - You have had a severe flare-up of COPD (a lung disease) requiring a ventilator - You have severe pneumonia requiring a ventilator **You may NOT be eligible if...** - Multiple organs in your body are failing at the same time - You have active bleeding in multiple organs Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREThe dynamics of airway resistance

Monitoring the dynamic changes in airway resistance in patients can be used to reflect the progression of pulmonary inflammation and determine the optimal timing for suctioning.

DIAGNOSTIC_TESTconventional suctioning

The timing for suctioning is determined based on clinical signs such as rhonchi and an elevated peak pressure.

Locations(3)

The First Affiliated Hospital of Bengbu Medical University

Bengbu, Anhui, China

Peking Union Medical College Hospital

Beijing, Beijing Municipality, China

the Second Affiliated Hospital of Zhejiang University School of Medicine

Hangzhou, Zhejiang, China

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NCT07375667

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