RecruitingNot ApplicableNCT07378059

The Analgesic Efficacy and Safety of Loxoprofen Sodium Patch in Patients With Herpes Zoster

The Analgesic Efficacy and Safety of Topical Patches (Loxoprofen Sodium Patch) in Patients With Herpes Zoster

Sponsor

Beijing Tiantan Hospital

Enrollment

750 participants

Start Date

Dec 15, 2025

Study Type

INTERVENTIONAL

Conditions

Pain Herpes Zoster

Summary

Herpes zoster (HZ) is characterized by a painful dermatomal rash and significantly affects quality of life, with acute pain increasing the risk of postherpetic neuralgia. Although early antiviral therapy limits viral replication, its analgesic effect is insufficient, and many patients experience inadequate relief despite stepwise use of non-opioids and opioids. Topical NSAIDs offer a promising alternative by delivering localized analgesia with reduced systemic exposure. Therefore, investigators hypothesize that loxoprofen sodium patch may effectively reduce the severity of HZ pain without significantly increasing adverse events.

Eligibility

Min Age: 18 Years

Inclusion Criteria6

\. Ages more than 18 years;
\. Patients with onset of HZ rash less than 90 days;
\. Experiencing moderate to severe HZ pain with an average pain score of at least 4 on a Numeric Rating Scale (NRS, 0 = no pain, 10 = worst possible pain);
\. Aspartate aminotransferase and alanine aminotransferase levels less than twice the upper limit of normal;
\. Estimated glomerular filtration rate of 30 mL/min per 1.73 m2 or higher;
\. Willing to sign the informed consent form and possessing sufficient cognitive and language abilities to comply with all the study requirements.

Exclusion Criteria5

\. History of taking loxoprofen sodium patch;
\. Patients with evidence of cutaneous or visceral dissemination of HZ infection (cutaneous dissemination is defined as more than 20 discrete lesions outside adjacent dermatomes) or ocular involvement of HZ;
\. History of intolerance or hypersensitivity to any active components or excipient of the loxoprofen sodium patch;
\. History of systemic immune diseases, organ transplantation, or cancers;
\. Pregnancy or breastfeeding.

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Interventions

DRUGConventional therapy group

In the conventional therapy group, treatments will include opioids, antiviral drugs and so on.

DRUGLoxoprofen sodium patch combined with conventional therapy group

In the loxoprofen sodium patch combined with conventional therapy group, apply the loxoprofen patch to the painful point near the herpes lesion. Use one patch per day, twice a day. In addition, the group will contain conventional treatment for HZ, except loxoprofen sodium patch, including opioids, antiviral drugs and so on.