Perineural Dextrose Versus Local Anesthetic Injections in Knee Osteoarthritis
A Prospective Evaluation of the Clinical Effectiveness of Perineural Dextrose and Conventional Local Anesthetic Injections in Patients With Symptomatic Knee Osteoarthritis
Ankara Training and Research Hospital
86 participants
Feb 2, 2026
OBSERVATIONAL
Conditions
Summary
This prospective observational study aims to compare the clinical effectiveness of perineural 5% dextrose injections and perineural local anesthetic injections in patients with symptomatic knee osteoarthritis. Adult patients receiving routine perineural injection therapy will be followed for six months. Pain intensity and functional outcomes will be assessed at baseline and at 1, 3, and 6 months after treatment using validated clinical assessment tools.
Eligibility
Inclusion Criteria4
- Symptomatic knee osteoarthritis
- Clinical/radiological diagnosis
- Knee pain ≥ 3 months
- Written informed consent
Exclusion Criteria5
- Prior knee surgery
- Recent intra-articular injection
- Inflammatory rheumatic disease
- Severe systemic or neurological disease
- Pregnancy or breastfeeding
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
Perineural injection of 5% dextrose solution administered around periarticular sensory nerves of the knee as part of routine clinical practice.
Perineural injection of local anesthetic administered around periarticular sensory nerves of the knee as part of routine clinical practice.
Locations(2)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07381621