RecruitingNot ApplicableNCT07386366

Wound Healing and Bacterial Adherence With Triclosan-Coated Sutures After Mandibular Impacted Third Molar Surgery

Evaluation of Soft Tissue Healing and Antibacterial Effectiveness of Triclosan-Coated Polyglactin 910 Sutures After Impacted Mandibular Third Molar Surgery: A Randomized Double-Blind Split-Mouth Clinical Trial


Sponsor

University of Medicine and Pharmacy at Ho Chi Minh City

Enrollment

14 participants

Start Date

Oct 7, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to learn if triclosan-coated absorbable stitches (polyglactin 910 sutures coated with triclosan, an antibacterial agent) help soft tissue heal better and have fewer bacteria stuck to the stitches after lower impacted wisdom tooth surgery in adults aged 18 to 35 years. The main questions it aims to answer are: 1. Does triclosan-coated polyglactin 910 suture lead to better soft-tissue wound healing than non-coated polyglactin 910 suture on postoperative days 3, 5, and 7 after mandibular impacted third molar surgery? 2. Does triclosan-coated polyglactin 910 suture result in a lower oral bacterial load adhered to the suture material than non-coated polyglactin 910 suture on postoperative days 3, 5, and 7 after mandibular impacted third molar surgery? Participants will: * Have surgery to remove two similar lower impacted wisdom teeth (one on each side) * Receive triclosan-coated stitches on one side and standard stitches on the other side, with the side assignment chosen at random * Return for follow-up visits on day three, day five, and day seven after surgery for healing checks, simple ratings of pain and swelling, and collection of a small stitch sample for bacterial testing.


Eligibility

Min Age: 18 YearsMax Age: 35 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is examining whether sutures coated with triclosan — an antibacterial agent — result in better wound healing and fewer bacteria on the stitches compared to standard sutures after wisdom tooth removal. Each participant has both lower wisdom teeth removed in separate surgeries, with one side receiving triclosan-coated stitches and the other receiving standard stitches, allowing a direct comparison within the same person. Healthy adults aged 18 to 35 with two similar impacted lower wisdom teeth and no active infections are eligible. Participation involves two separate surgical visits four weeks apart, plus follow-up checks on days 3, 5, and 7 after each procedure where a small stitch sample is collected for bacterial testing. This summary was prepared to help patients understand the study in plain language.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICETriclosan-coated Polyglactin 910 suture

Absorbable braided polyglactin 910 suture coated with triclosan for wound closure after mandibular impacted third molar surgery.

DEVICENon-coated polyglactin 910 suture

Absorbable braided polyglactin 910 suture without triclosan coating for wound closure after mandibular impacted third molar surgery.


Locations(1)

Specialized Dental Clinic, University of Medicine and Pharmacy at Ho Chi Minh City

Ho Chi Minh City, Vietnam

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NCT07386366


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