RecruitingNot ApplicableNCT07387432

Role of Exercise in PRISm and Subsequent Development of COPD

Role of Exercise in Functional Capacity of Smokers and Subsequent Development of Chronic Obstructive Pulmonary Disease


Sponsor

The University of Hong Kong

Enrollment

90 participants

Start Date

Jul 14, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

Preserved Ratio Impaired Spirometry (PRISm) describes individual with spirometry findings of forced expiratory volume (FEV1) and forced vital capacity (FVC) ratio greater than 0.7 but with the FEV1 less than 80% predicted. While the spirometry findings of individuals with PRISm can be transited into obstructive pattern, remains at PRISm or become normal spirometry, limited evidence is on the role of exercise in the course of PRISm. This study aims to investigate the role of exercise, namely exercise with telehealth and walking exercise, together with smoking cessation advice, would alter the clinical course of PRISm.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating whether exercise can help prevent people with a specific breathing pattern called PRISm (preserved ratio impaired spirometry) — where lung function is reduced but the ratio of two breathing measurements is normal — from developing COPD. PRISm is considered a transitional state between healthy lung function and full COPD. **You may be eligible if...** - You are 18 years of age or older - You are a current or former smoker - Your breathing test (spirometry) shows the PRISm pattern (FEV1/FVC at or above 0.7 but FEV1 below 80% predicted) - You are able to walk without assistance - You can provide informed consent **You may NOT be eligible if...** - You are under 18 - You have never smoked - Your spirometry does not show PRISm, or you are unable to perform a spirometry test - You need help walking - You are unable to give informed consent Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

BEHAVIORALExercise with telehealth group

Participants will attend telehealth physiotherapy class for exercise. Smoking cessation advice will be given.

BEHAVIORALExercise group

Participants will exercise with walking. Smoking cessation advice will be given.

BEHAVIORALNo exercise group

No exercise instruction will be given. Participants are encouraged to exercise. Smoking cessation advice will be given.


Locations(1)

The University of Hong Kong, Queen Mary Hospital

Hong Kong, China

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT07387432


Related Trials