RecruitingNot ApplicableNCT07387952

The Safety and Efficacy of Fecal Microbiota Transplantation Combined With Nutritional Intervention in the Treatment of Functional Constipation：a Pilot Study

Sponsor

Peking Union Medical College Hospital

Enrollment

5 participants

Start Date

Jul 30, 2025

Study Type

INTERVENTIONAL

Conditions

Chronic Constipation Fecal Microbiota Transplantation (FMT)Constipation - Functional

Summary

Chronic constipation is a common gastrointestinal disease with a global prevalence of about 15%, significantly affecting daily life and quality of life. Traditional treatments primarily rely on laxatives, which may lead to adverse effects with prolonged use, while surgical interventions have limited patient acceptance. Recent studies indicate that gut microbiota therapies-including probiotics, prebiotics, synbiotics, postbiotics, and fecal microbiota transplantation (FMT)-can effectively manage chronic constipation. This study aims to investigate the safety and efficacy of FMT combined with a prebiotic nutritional intervention (using a co-localization strategy) in the treatment of functional constipation. Additionally, the investigators will explore changes in fecal microbiota and metabolomic profiles following the treatment.

Eligibility

Min Age: 18 YearsMax Age: 70 Years

Inclusion Criteria7

Age: 18 to 70.
Diagnostic criteria: Functional constipation (FC) in accordance with Rome IV criteria, which should meet the following conditions:
Symptom requirements: The following at least 2 items should occur in ≥25% of bowel movements: a. Straining during defecation; b. Hard stool (Bristol Stool Classification score 1-2); c. Feeling of incomplete evacuation; d. Rectal obstruction sensation; e. Need for finger assistance during defecation; f. Spontaneous bowel movements \<3 times per week.
It is rare to have loose stools without laxatives.
Exclusion of irritable bowel syndrome (IBS): IBS diagnosis criteria not meeting Rome IV.
Disease course requirements: Symptoms persist for at least 6 months and meet the above criteria within the last 3 months.
Traditional treatment methods (dietary intervention, at least two laxatives or probiotics) are ineffective.

Exclusion Criteria9

Pregnancy or lactation.
Unable to take the intervention product or complete the examination as required.
Language expression disorder or mental illness.
Physical examination showed severe liver and kidney dysfunction.
Acute gastrointestinal disease within 4 weeks.
Constipation caused by surgery in the past 4 weeks.
History or abnormal examination: cancer, severe enteritis, intestinal obstruction, inflammatory bowel disease, hypothyroidism, mental illness, stroke, heart disease, cirrhosis, renal failure, hematopoietic system diseases, organic bowel disease suggested by colonoscopy or imaging.
Participation in other clinical trials within 3 months prior to enrollment.
Other health problems are not suitable for participation in the study.

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Interventions

PROCEDUREFMT

In this group, colonoscopy is performed and a colostomy is placed in the ileocecal region. Bacterial infusion is performed for 3 days with 100ml graft per day. Within 30 minutes after receiving the microbiota transplantation, take the high dietary fiber preparation and dissolve it in water according to the instructions. Blood, stool, and colonoscopy-derived mucosal samples are collected before and after FMT and Researchers conduct follow-ups.