Impact of Serum Progesterone Levels on Embryo Transfer Day on Clinical Pregnancy
Impact of Serum Progesterone Levels on Embryo Transfer Day on Clinical Pregnancy in Frozen-thawed Embryo Transfer Cycles Using Hormone Replacement Therapy: a Prospective Observational Study
Chinese University of Hong Kong
370 participants
Jan 20, 2026
OBSERVATIONAL
Conditions
Summary
Hypotheses: We hypothesize that serum progesterone levels on the day of embryo transfer in HRT-FET cycles are positively associated with clinical pregnancy rates. Aims: To evaluate the relationship between serum progesterone levels on embryo transfer day and clinical pregnancy outcomes in frozen-thawed embryo transfer cycles using hormone replacement therapy (HRT). Primary outcome: To compare the incidence of clinical pregnancy outcome in those infertility patients undergoing frozen embryo transfer with caterized Progesterone level on the day of embryo transfer Secondary outcomes: Biochemical pregnancy rate. Implantation rate. Early pregnancy loss rate. Ectopic pregnancy rate.
Eligibility
Inclusion Criteria4
- Patients undergoing FET cycles
- Infertility patients aged >18 years old and < 42 years old
- BMI < 30 kg/m2
- Transfer of at least one good-quality embryo.
Exclusion Criteria2
- Severe endocrine disorders (e.g., thyroid dysfunction, premature ovarian failure).
- Severe uterine factors without treatment (severe endometriosis, extensive or subendometrial fibroid, uterine adherent, endometrial polyps)
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Locations(1)
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NCT07388797