Clinical Study on the First-line Treatment of Advanced Colorectal Cancer With Simultaneous Infusion of Levozolinate for Injection and 5-FU

This trial is testing a first-line chemotherapy regimen for people with advanced colorectal cancer that has spread or cannot be surgically removed. It is testing the combination of a newer drug called levolinate (levozolinate) given at the same time as 5-FU, to see if this improves outcomes compared to standard treatment. **You may be eligible if...** - You are 18 to 75 years old - You have unresectable or metastatic colorectal cancer confirmed by biopsy - You have not yet received chemotherapy for your metastatic cancer - The genetic profile of your tumor (RAS and BRAF status) and primary tumor location are known - You have at least one measurable tumor and your blood counts and organ function are within acceptable ranges **You may NOT be eligible if...** - You have already received treatment for metastatic colorectal cancer - You have serious heart, lung, liver, or kidney problems - You have active serious infections or uncontrolled other medical conditions - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.