Advanced Colorectal Cancer Clinical Trials

21 recruitingLast updated: June 17, 2026

There are 21 actively recruiting advanced colorectal cancer clinical trials across 14 countries. Studies span Phase 2, Phase 1, Phase 3, Early Phase 1, Phase 4. Top locations include Beijing, Beijing Municipality, China, Shanghai, Shanghai Municipality, China, San Antonio, Texas, United States. Updated daily from ClinicalTrials.gov.


Advanced Colorectal Cancer Trials at a Glance

21 actively recruiting trials for advanced colorectal cancer are listed on ClinicalTrialsFinder across 6 cities in 14 countries. The largest study group is Phase 2 with 9 trials, with the heaviest enrollment activity in Beijing, Shanghai, and San Antonio. Lead sponsors running advanced colorectal cancer studies include Shanghai Changzheng Hospital, Brenus Pharma, and Biogrid.

Browse advanced colorectal cancer trials by phase

Treatments under study

About Advanced Colorectal Cancer Clinical Trials

Looking for clinical trials for Advanced Colorectal Cancer? There are currently 13 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Advanced Colorectal Cancer trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Advanced Colorectal Cancer clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 21 trials

Recruiting
Phase 2

Open-label Phase 2 Study of Avutometinib (RAF/MEK Clamp) in Combination With Defactinib (FAK Inhibitor) and Cetuximab in Patients With Unresectable, Anti-EGFR-Refractory Advanced Colorectal Cancer

Advanced Colorectal Cancer
M.D. Anderson Cancer Center33 enrolled1 locationNCT06369259
Recruiting
Phase 1

A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Anti-tumor Activity of CBI-1214 T Cell Engager in Participants With Advanced or Metastatic MSS/MSI-L Colorectal Cancer

Colorectal, CancerColon CancerCRC+4 more
Cartography Biosciences80 enrolled8 locationsNCT07321106
Recruiting
Phase 1

A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations.

MelanomaNon-small Cell Lung CancerThyroid Cancer+2 more
Pfizer267 enrolled40 locationsNCT05355701
Recruiting
Phase 3

Efficacy of the Use of Neoadjuvant With/Without Hyperthermic Intraperitoneal Chemotherapy in the Treatment of Locally Advanced Colon Cancer

Locally Advanced Colorectal Cancer
Maimónides Biomedical Research Institute of Córdoba1,083 enrolled1 locationNCT06783491
Recruiting
Phase 2

Evaluation of RBS2418 in Patients With Advanced, Metastatic, and Progressive Colorectal Cancer

Metastatic Colorectal CancerAdvanced Colorectal Cancer
Riboscience, LLC.150 enrolled5 locationsNCT06824064
Recruiting
Phase 3

FOLICOLOR TRIAL: Following Therapy Response Through Liquid Biopsy in Metatstatic Colorectal Cancer Patients

Advanced Colorectal Cancer
University Hospital, Antwerp150 enrolled9 locationsNCT07558083
Recruiting
Phase 2

TL938 and Trastuzumab for Patients With HER2-positive Metastatic Colorectal Cancer

Colorectal Cancer MetastaticAdvanced Colorectal Cancer
Suzhou Teligene Ltd.80 enrolled1 locationNCT06589830
Recruiting
Phase 1

Clinical Study of MSH2-/- Tumor Cell Vaccines for Advanced pMMR Colorectal Cancer Patients

pMMR/MSS Advanced Colorectal Cancer
West China Hospital9 enrolled2 locationsNCT07510308
Recruiting
Phase 1

A First-in-human Study of BGB-53038, a Pan-KRAS Inhibitor, Alone or in Combinations in Participants With Advanced or Metastatic Solid Tumors With KRAS Mutations or Amplification

Advanced Gastric CancerMetastatic Solid TumorsAdvanced Non-squamous Non-small-cell Lung Cancer+4 more
BeiGene514 enrolled17 locationsNCT06585488
Recruiting
Phase 2

Clinical Study on the First-line Treatment of Advanced Colorectal Cancer With Simultaneous Infusion of Levozolinate for Injection and 5-FU

Advanced Colorectal Cancer
Chinese PLA General Hospital583 enrolled1 locationNCT07391618
Recruiting
Phase 1Phase 2

First-in-human Trial of STC-1010, an Immunotherapy, in Patients With Unresectable Locally Advanced or Metastatic Colorectal Cancer

Unresectable Metastatic Colorectal CancerUnresectable Locally Advanced Colorectal Cancer
Brenus Pharma90 enrolled9 locationsNCT06934538
Recruiting
Phase 1

Trial of ProAgio in Advanced/Metastatic Colorectal Cancer

Metastatic Colorectal CancerAdvanced Colorectal Cancer
University of Alabama at Birmingham27 enrolled1 locationNCT06867822
Recruiting
Phase 2

Neoadjuvant ADG126 and Pembrolizumab in Locally Advanced Colorectal Cancer

Locally Advanced Colorectal Cancer
National University Hospital, Singapore20 enrolled1 locationNCT06846268
Recruiting
Phase 2

A Phase 2 Study Evaluating the Safety and Efficacy of JS207 With or Without JS015 in Combination With Chemotherapy in Patients With Colorectal Cancer

Advanced Colorectal Cancer
Shanghai Junshi Bioscience Co., Ltd.60 enrolled2 locationsNCT06885385
Recruiting
Phase 2

The Aim of This Study is to Assess the Efficacy and Safety of Chidamide, Regorafenib in Combination With Iparomlimab and Tuvonralimab for the Treatment of Advanced Colorectal Cancer in Third-line Therapy and Subsequent Lines.

Advanced Colorectal Cancer in the Third-line Treatment and BeyondpMMR/MSS Advanced Colorectal Cancer
Shanghai Changzheng Hospital60 enrolled1 locationNCT06930118
Recruiting
Phase 2

CapeOX Combined With Bevacizumab Plus Anti-PD1 Antibody as Neoadjuvant Therapy for Microsatellite Stable Locally Advanced Rectal Cancer

Locally Advanced Colorectal Cancer
Shanghai Changzheng Hospital30 enrolled1 locationNCT05585814
Recruiting

The Role of 18F-FDG and 68Ga-FAPI PET/CT in the Diagnosis and the Efficacy Evaluation of Advanced Colorectal Cancer (peritoneal Metastasis With/without Other Metastases)

Advanced Colorectal Cancer
Ruijin Hospital30 enrolled1 locationNCT06601075
Recruiting
Phase 4

Safety and Efficacy of Pembrolizumab in Combination with Bevacizumab + CapeOX in the Neoadjuvant Treatment of RAS-mutated, BRAF Wild-type, Microsatellite-stabilized, Locally Advanced Colorectal Cancer

Locally Advanced Colorectal Cancer
yangjianjun20 enrolled1 locationNCT06550453
Recruiting
Early Phase 1

Chemokine and Co-stimulatory Molecule-modified Mesenchymal Stem Cells for the Treatment of Advanced Colorectal Cancer

Advanced Colorectal Cancer
Shanghai East Hospital30 enrolled1 locationNCT06446050
Recruiting

A Prospective Cohort Study of Advanced Colorectal Cancer Treated With Oxaliplatin and Irinotecan.

Advanced Colorectal Cancer
Sun Yat-sen University500 enrolled1 locationNCT05731336