RecruitingNot ApplicableNCT07393165

Levothyroxine Treatment on Cardiac Function in Children With Subclinical Hypothyroidism

The Effect of Levothyroxine Treatment on Cardiac Function in Children With Subclinical Hypothyroidism

Sponsor

Tanta University

Enrollment

40 participants

Start Date

May 24, 2025

Study Type

INTERVENTIONAL

Conditions

Cardiac Function Subclinical Hypothyroidism Children Levothyroxine

Summary

This study aims to evaluate the effect of the treatment with levothyroxine on cardiac function in children with subclinical hypothyroidism.

Eligibility

Min Age: 4 YearsMax Age: 15 Years

Inclusion Criteria3

Age from 4 to 15 years.
Both sexes.
Patients with stable elevated thyroid-stimulating hormone (TSH) ≥ 4.5 mIU/L with normal free T4 and ft3 in different measurement 4 - 6 weeks apart.

Exclusion Criteria11

Overweight and obesity
Hypertension
Previous use of levothyroxine, antiepileptic drugs, or cardiac drugs within the last 6 months.
Arrhythmia.
Congenital or acquired heart disease
Liver or kidney disease
Hyperlipidemia
Diabetes
Infectious diseases
Respiratory diseases
Malignancies

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Interventions

DRUGL-thyroxine

Children with subclinical hypothyroidism who will receive L-thyroxine treatment in a dose of 2μg/kg/d (the smallest dose can be given) and the dose will be titrated every 4 weeks until a normal thyroid-stimulating hormone (TSH) level is maintained.