RecruitingNCT07397975

Speech-based Assessment of Relapse Risk in People With Psychosis

A Prospective Multicenter Study for Relapse Risk Assessment Through Language Analysis in Individuals With Psychosis

Sponsor

Philipp Homan

Enrollment

360 participants

Start Date

Jan 29, 2026

Study Type

OBSERVATIONAL

Conditions

Psychotic Disorder

Summary

This observational, multinational study assesses the feasibility of speech and self-report data collection across six languages for Artificial Intelligence (AI)-driven relapse risk estimation in psychosis. Over 12 months, patients at risk of relapse and healthy controls will provide weekly speech recordings and self-report data for automated analysis. Risk scores will be stored but not shared with treating clinicians. Independent clinical evaluations ensure data quality and validation. The study lays the foundation for future Clinical Decision Support System (CDSS) research and explores novel speech markers for relapse prediction while minimizing participant burden.

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether analyzing speech patterns using artificial intelligence can detect early warning signs of relapse in people with psychotic disorders (like schizophrenia). Participants will make short recordings of their voice regularly, and AI will analyze features like rhythm, pausing, and word choice to look for changes linked to worsening mental health. **You may be eligible if...** - You are between 18 and 65 years old - You are a native or fluent speaker of English, German, Dutch, French, Czech, or another study language - You are able to provide informed consent - You are not regularly taking prescription medications (for healthy volunteer group) **You may NOT be eligible if...** - You are under 18 or over 65 - You are unable to understand or consent to the study - You have significant hearing or speech difficulties that would prevent recording Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERWeekly online speech assessments via a smartphone app collect speech and self-report data. Recordings are securely transferred and analyzed by an AI-based backend to calculate relapse risk scores.

The intervention is a weekly online assessment of speech, to detect subtle characteristics of psychotic speech. These recordings are made through a speech data collection tool: a smartphone app with implemented tasks for the collection of behavioral response data (speech and self-report). Data is then transferred to a safe repository (TSD) to be analysed by an AI-based speech data analysis algorithm: a backend system will run the predictor code to calculate automatic relapse risk scores.