RecruitingNCT07401771

Exercise Cardiovascular Magnetic Resonance In Heart Failure With Preserved Ejection Fraction

Sponsor

Mayo Clinic

Enrollment

400 participants

Start Date

Mar 1, 2026

Study Type

OBSERVATIONAL

Conditions

Heart Failure With Preserved Ejection Fraction

Summary

The purpose of this study is to internally validate low-field Ex-CMR as a noninvasive tool for diagnosing, phenotyping, and risk stratifying HFpEF in patients with exertional dyspnea.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Inclusion Criteria5

Informed consent obtained
Three groups will be enrolled:
HFpEF (cardiologist-adjudicated diagnosis as verified by PI, EF≥50%)
Non-cardiac dyspnea (patients have dyspnea but were found on invasive exercise testing not to have HFpEF).
Healthy volunteers with no history of dyspnea or effort intolerance.

Exclusion Criteria8

Contraindication for low-field CMR, as indicated in MRI safety screening checklist (Research Document #1)
Patient inability or unwillingness to undergo Ex-CMR
Cardiac implants, mechanical or biological valve, causing artifacts that compromise the quality of data
Hospitalization for heart failure in the preceding 30 days.
Large R-R interval variation, caused by frequent premature ventricular contractions or non-sinus rhythms such as persistent atrial fibrillation, which, in the opinion of the investigators, compromises the quality of data acquisition, image analysis and disrupts the consistency of the cohorts
Myocardial infarction or unstable angina pectoris
Planned coronary, carotid, or peripheral artery revascularization
Other causes of dyspnea as indicated in patients' medical history based upon the opinion of the PI, such as restrictive cardiomyopathy or infiltrative conditions (e.g., amyloidosis), hypertrophic obstructive cardiomyopathy, primary pulmonary arterial hypertension, more than moderate chronic obstructive pulmonary disease, right heart failure due to pulmonary disease, complex congenital heart disease, severe anemia, or more than moderate mitral or aortic heart valve disease).

Interventions

DIAGNOSTIC_TESTExercise Cardiovascular Magnetic Resonance

Exercise Cardiovascular Magnetic Resonance is a non-invasive imaging technique that combines cardiovascular magnetic resonance (CMR) with exercise stress testing.