Effects of Variations in Caffeinated Beverages on Well-being
A Randomized, Double-Blind, Parallel Trial to Assess Subjective and Physiological Responses to Consumption of Caffeinated Beverages in Healthy Adults With a Caffeine Routine
GUAYAKI SUSTAINABLE RAINFOREST PRODUCTS, INC.
75 participants
Jan 5, 2026
INTERVENTIONAL
Conditions
Summary
This study will evaluate post-beverage subjective caffeine responses and physiological responses to caffeinated beverage variations in generally healthy adults.
Eligibility
Inclusion Criteria10
- Males or females, ≥18 to ≤55 years of age
- BMI ≥18.5 and \<35.0 kg/m2
- Generally good health
- Participant currently and consistently has a sweetened caffeine routine
- Participant is willing to substitute their current caffeine routine for the test beverage daily
- Participant has never consumed the test beverage or similar products
- Participant currently owns a wearable and is willing to use and connect the wearable device
- Willing to use personal smart phone, tablet, or personal computer with stable internet connection
- Willing and able to comply with all study procedures
- Willing to adhere to all study procedures, including lifestyle considerations and sign forms providing informed consent to participate in the study
Exclusion Criteria21
- History or presence, on the basis of the health history, of clinically important condition or disease states
- Is currently following, or planning to be on, a weight loss regimen
- Weight loss or gain \>4.5 kg
- History of gastrointestinal surgery for weight reducing purposes or gastrointestinal (GI) conditions
- History of an eating disorder (e.g., anorexia nervosa or bulimia nervosa, binge eating) at the discretion of the Clinical Investigator.
- History of unconventional sleep patterns (e.g., night shift) or diagnosed sleep disorder
- Use of tobacco/nicotine products
- Use of hemp/marijuana products
- Unstable use of any prescription medication
- Use of any medications(s) or dietary supplement(s), containing caffeine, or interacting with caffeine
- Recent history of alcohol or substance abuse
- Exposed to any non-registered drug product
- Self-report of hypertension/high blood pressure without use of hypertensive medications
- Any known allergy or intolerance to any ingredients contained in the study product
- Any signs or symptoms of active infection of clinical relevance
- History or presence of cancer, except for non-melanoma skin cancer
- History of any major trauma or major surgical event
- Female who is pregnant, planning to be pregnant during the study period, lactating
- An employee, close relative of an employee, or participant who has a financial interest in Sponsor company or any other caffeine beverage company.
- Any condition the Investigator believes would interfere with the participant's ability to provide informed consent or comply with the study protocol
- A clinically significant medical condition that is affected by caffeine
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Interventions
Participants will consume a caffeinated beverage with variations in sweetener and caffeine content.
Participants will consume a caffeinated beverage with variations in sweetener and caffeine content.
Participants will consume a caffeinated beverage with the control level of sweetener and caffeine content.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07404254