Caffeine Clinical Trials

8 recruitingLast updated: May 13, 2026

There are 8 actively recruiting caffeine clinical trials across 4 countries. Studies span Not Applicable, Phase 4. Top locations include Alcalá de Henares, Madrid, Spain, San Francisco, California, United States, Cairo, Egypt. Updated daily from ClinicalTrials.gov.


Caffeine Trials at a Glance

8 actively recruiting trials for caffeine are listed on ClinicalTrialsFinder across 6 cities in 4 countries. The largest study group is Not Applicable with 6 trials, with the heaviest enrollment activity in Alcalá de Henares, San Francisco, and Cairo. Lead sponsors running caffeine studies include Alberto Pérez-López, GUAYAKI SUSTAINABLE RAINFOREST PRODUCTS, INC., and Cairo University.

Browse caffeine trials by phase

Treatments under study

About Caffeine Clinical Trials

Looking for clinical trials for Caffeine? There are currently 6 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Caffeine trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Caffeine clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 18 of 8 trials

Recruiting
Not Applicable

Sublingual Caffeine on Reducing Recovery Time and Postoperative Agitation in Elderly Patients Undergoing General Anesthesia

postoperative agitationElderly PatientsGeneral Anesthesia+3 more
Cairo University50 enrolled1 locationNCT07536568
Recruiting
Not Applicable

Effects of Variations in Caffeinated Beverages on Well-being

HealthyCaffeineBeverage Intake
GUAYAKI SUSTAINABLE RAINFOREST PRODUCTS, INC.75 enrolled1 locationNCT07404254
Recruiting
Not Applicable

Effects of Caffeinated Beverages on Well-being

HealthyCaffeineBeverage Intake
GUAYAKI SUSTAINABLE RAINFOREST PRODUCTS, INC.150 enrolled1 locationNCT07357818
Recruiting
Not Applicable

Caffeine Optimization Versus Standard Caffeine Dosage (2B-2)

Sleep DeprivationCaffeine
University of Arizona180 enrolled2 locationsNCT05588934
Recruiting
Phase 4

The Caffeine Therapy in the Fetal to Neonatal Transition

Mechanical Ventilation ComplicationVentilator Lung; NewbornCaffeine
Hospital de Clinicas de Porto Alegre50 enrolled1 locationNCT05454332
Recruiting
Phase 4

Effects of Caffeine on Reinforcement Learning in Healthy Adults Using PET/MRI

HealthyCaffeineAdenosine+1 more
Hsiao-Ying Wey12 enrolled1 locationNCT06763172
Recruiting
Not Applicable

Caffeine, CYPA12 and Resistance Training

CYP1A2 PolymorphismCaffeine and Resistance Training
Alberto Pérez-López48 enrolled1 locationNCT06610123
Recruiting
Not Applicable

Caffeine, CYPA12 and Resistance Exercise

CYP1A2 PolymorphismCaffeine and Resistance Exercise
Alberto Pérez-López60 enrolled2 locationsNCT06610110