Vaginal DHEA to Improve Vaginal Health After Radiation for Women With Gynecologic, Anal or Rectal Cancer

This study tests whether a vaginal hormone treatment called DHEA (a mild hormonal suppository) can improve vaginal dryness, discomfort, and sexual health in women who have gone through pelvic radiation for cancers such as anal, rectal, cervical, vaginal, or vulvar cancer. **You may be eligible if...** - You have been diagnosed with anal, rectal, cervical, vaginal, or vulvar cancer - You are receiving or have received pelvic radiation with the goal of cure - You have had chemotherapy before or during radiation (this is allowed) - You are menopausal (over 50 with no period for 12 months, or had both ovaries removed) **You may NOT be eligible if...** - You have scleroderma, lupus, or mixed connective tissue disorder - You have had prior pelvic radiation - You have endometrial cancer or endometrial hyperplasia - You have unexplained vaginal bleeding - You are currently using hormonal medications (estrogen, progestin, or DHEA) - You have a history of breast cancer - You are receiving radiation for palliative (not curative) purposes Talk to your doctor to see if this trial is right for you.