Feasibility Study of the Supira System in Patients Undergoing HRPCI With Support Beyond the PCI Procedure

This study tests the Supira heart support system in patients undergoing a high-risk heart procedure called percutaneous coronary intervention (PCI — a procedure to open blocked heart arteries) who also have existing heart failure. The device provides mechanical support to the heart during and beyond the procedure. **You may be eligible if...** - You have pre-existing heart failure (NYHA Class II, III, or IV) and a weakened heart (ejection fraction at or below 45%) - You have serious coronary artery disease: unprotected left main artery disease, last remaining open vessel, or three-vessel disease - Your doctor believes you could benefit from heart support beyond the procedure itself - You or your representative has given consent **You may NOT be eligible if...** - You had a stroke within the past 6 months or have permanent neurological damage from a prior stroke - You have moderate or severe aortic valve disease - You have severe liver disease or are on kidney dialysis - You have a history of heparin-induced low platelet count - You have a known bleeding disorder or blood clotting problems - You are pregnant or breastfeeding - You are currently enrolled in another device or drug trial Talk to your doctor to see if this trial is right for you.