Coronary Arterial Disease (CAD) Clinical Trials

44 recruitingLast updated: May 4, 2026

Coronary Arterial Disease (CAD) Trials at a Glance

43 actively recruiting trials for coronary arterial disease (cad) are listed on ClinicalTrialsFinder across 6 cities in 30 countries. The largest study group is Not Applicable with 17 trials, with the heaviest enrollment activity in Beijing, Cincinnati, and Atlanta. Lead sponsors running coronary arterial disease (cad) studies include Kutahya Health Sciences University, Tampere Heart Hospital, and University of Florida.

Browse coronary arterial disease (cad) trials by phase

Treatments under study

About Coronary Arterial Disease (CAD) Clinical Trials

Looking for clinical trials for Coronary Arterial Disease (CAD)? There are currently 44 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Coronary Arterial Disease (CAD) trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Coronary Arterial Disease (CAD) clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 43 trials

Recruiting
Not Applicable

Prolonged Chest Tube Treatment to Reduce Rates of Atrial Fibrillation Following Cardiac Surgery

Coronary Arterial Disease (CAD)Valve ReplacementAortic Surgery
Region Skane624 enrolled1 locationNCT06800781
Recruiting
Not Applicable

AGENT DCB STANCE: Safety and Effectiveness Study of AGENT Drug-Coated Balloon Compared to Standard of Care Percutaneous Coronary Intervention (PCI) Treatment for de Novo Coronary Lesions

Coronary Arterial Disease (CAD)de Novo Lesions in Native Coronary Arteries
Boston Scientific Corporation1,616 enrolled46 locationsNCT06959524
Recruiting
Not Applicable

Orbital Atherectomy vs Intravascular Lithotripsy for the Treatment of Calcified Coronary Nodules (ORBIT-SHOCK).

Chronic Coronary SyndromeCoronary Arterial Disease (CAD)Percutaneous Coronary Intervention (PCI)+6 more
Spanish Society of Cardiology50 enrolled6 locationsNCT06736665
Recruiting

Artificial Intelligence Based Timing, Infarct Size and Outcomes in Acute Coronary Occlusion Myocardial Infarction

Coronary Arterial Disease (CAD)Acute Coronary Syndrome (ACS) Undergoing Percutaneous Coronary Intervention (PCI)
Azienda Ospedaliera di Bolzano1,500 enrolled1 locationNCT06910436
Recruiting

Restrospective Analysis of MACE in Patients Treated With Drug-elluting Balloons.

Coronary Arterial Disease (CAD)Bifurcation Coronary DiseaseRestenosis, Coronary
Olivier F. Bertrand1,500 enrolled1 locationNCT06972225
Recruiting
Not Applicable

FORWARD CAD IDE Study

Coronary Arterial Disease (CAD)
Shockwave Medical, Inc.408 enrolled34 locationsNCT06662500
Recruiting
Not Applicable

Intracoronary Cryotherapy Effect on Stabilization of Vulnerable Plaque in Patients With Stable Angina or ACS - A Traditional Feasibility Study

Coronary Arterial Disease (CAD)
Cryotherapeutics SA30 enrolled3 locationsNCT06939374
Recruiting
Not Applicable

Super High-pressure Balloon Versus Intravascular Lithotripsy to Prepare Severely Calcified Coronary Lesions

Coronary Arterial Disease (CAD)PCICalcified Coronary Lesions
Nanjing First Hospital, Nanjing Medical University78 enrolled3 locationsNCT07093788
Recruiting

Safety and Effectiveness of the Crystalline Sirolimus-Eluting Device in Patients With Coronary Artery Disease

Coronary Arterial Disease (CAD)NSTEMI - Non-ST Segment Elevation Myocardial Infarction (MI)Stable Angina, Unstable Angina, NSTEMI
Fundación Interhospitalaria para la Investigación Cardiovascular FIC1,118 enrolled1 locationNCT07444957
Recruiting
Phase 4

Prasugrel Monotherapy Reduced Dose in Acute and Chronic Coronary Syndrome Patients After Percutaneous Coronary Intervention (PROMOTE)

Coronary Arterial Disease (CAD)Percutaneous Coronary Intervention (PCI)
J.P.S Henriques300 enrolled1 locationNCT06916520
Recruiting

Validation of Sudden Cardiac Arrest Risk Factors in Patients With CAD

Sudden Cardiac DeathCoronary Arterial Disease (CAD)Sudden Cardiac Arrest
Tampere Heart Hospital1,500 enrolled3 locationsNCT07444931
Recruiting
Phase 4

The Switching Antiplatelet-9 (SWAP-9) Study

Coronary Arterial Disease (CAD)
University of Florida90 enrolled1 locationNCT06588595
Recruiting
Not Applicable

Feasibility Study of the Supira System in Patients Undergoing HRPCI With Support Beyond the PCI Procedure

Heart FailureHeart DiseaseCoronary Arterial Disease (CAD)
Supira Medical45 enrolled2 locationsNCT07407816
Recruiting
Phase 2

Focused Orticumab Research for Treating Inflammation in Coronary Arteries

Heart DiseaseInflammationCoronary Arterial Disease (CAD)+3 more
Abcentra240 enrolled41 locationsNCT06927739
Recruiting

Drug-Coated Coronary Balloons in Different Clinical Scenarios

Coronary Arterial Disease (CAD)
Kutahya Health Sciences University1,500 enrolled5 locationsNCT06915597
Recruiting
Not Applicable

Shockwave Intervention for Enhanced Wound Healing in No-touch Pedicle Saphenous Vein Graft Harvesting for Coronary Artery Bypass Grafting

Coronary Arterial Disease (CAD)
Medical University Innsbruck120 enrolled1 locationNCT07068776
Recruiting
Not Applicable

Randomised Trial of Dual Device Treatment Involving Drug-coated Balloon Angioplasty and Drug-eluting Stent Implantation Compared to Single Device Treatments in Patients With Diabetes Mellitus

Diabetes MellitusCoronary Arterial Disease (CAD)de Novo Coronary Lesions+1 more
Royal College of Surgeons, Ireland120 enrolled1 locationNCT07303439
Recruiting
Phase 4

Effectiveness of Interventional Therapy for Non-Flow-Limiting Vulnerable Plaques

Coronary Arterial Disease (CAD)Vulnerable Coronary PlaquesThin-cap fIbroatheroma
Beijing Anzhen Hospital2,190 enrolled1 locationNCT06855537
Recruiting
Phase 4

Dual Antiplatelet Therapy Escalation From Standard-dose Clopidogrel to Low-Dose Prasugrel in Patients With High Bleeding and Ischemic Risk Undergoing PCI: A Prospective, Randomized Pharmacodynamic Study (TAILOR-BLEED-2)

Coronary Arterial Disease (CAD)Percutaneous Coronary Intervention (PCI)
University of Florida40 enrolled1 locationNCT07025148
Recruiting
Phase 4

Pre-trial of Clinical Trial of Traditional Chinese Medicine Treatment for Elderly Patients With Coronary Heart Disease Who Are Still Symptomatic After Optimal Medical Treatment

Coronary Arterial Disease (CAD)
China National Center for Cardiovascular Diseases120 enrolled1 locationNCT07041359