Safety and Efficacy of TollB-001 Tablets in Moderate to Severe Rheumatoid Arthritis

This study tests the safety and effectiveness of a new oral drug called TollB-001 in adults with moderate to severe rheumatoid arthritis (RA) — a condition where the immune system attacks the joints causing pain, swelling, and stiffness — whose symptoms have not improved adequately with standard medications. **You may be eligible if...** - You are 18 to 70 years old - You have been diagnosed with rheumatoid arthritis - Your disease is moderately to severely active (DAS28-CRP score above 3.2) - You have elevated inflammation markers in your blood - You have previously tried at least one conventional RA medication (such as methotrexate or hydroxychloroquine) without adequate benefit **You may NOT be eligible if...** - You have previously used JAK inhibitor drugs (like tofacitinib, baricitinib) or biologic RA drugs - You have other immune or inflammatory conditions beyond RA - You have an active infection, tuberculosis, or history of cancer - You have severe heart, liver, or kidney disease - You are pregnant, breastfeeding, or not using effective contraception - You have positive HIV, active hepatitis B or C Talk to your doctor to see if this trial is right for you.