RecruitingNot ApplicableNCT07412028

Identification of Women With Severe Insulin Resistant Syndromes of Genetic Origin Among Patients With "Classic" Polycystic Ovary Syndrome (PCOS)

Sponsor

Assistance Publique - Hôpitaux de Paris

Enrollment

81 participants

Start Date

Jul 21, 2026

Study Type

INTERVENTIONAL

Conditions

Polycystic Ovary Syndrome Familial Partial Lipodystrophy LMNA (LaMin Nuclear A) Related Disorders

Summary

Diagnostic case-control study (1 case for 2 controls). Inclusion of patients with severe insulin resistance syndrome of genetic origin, then inclusion of controls: patients examined for PCOS in day hospital with matching age (+/- 5 years) and Body mass index (+/- 5kg/m2).

Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 45 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying Biological analysis, Genetic analysis, and others for people with familial partial lipodystrophy, lmna (lamin nuclear a) related disorders, and other related conditions. The study is currently recruiting participants at 1 location. People eligible for this study include women aged 18 Years to 45 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

GENETICGenetic analysis

Analyses of the insulin resistance and lipodystrophy gene panel revealed pathogenic or highly susceptible variants in control PCOS patients

OTHERBiological analysis

Measurement of adipokines

OTHERimaging test

DEXA (Dual-Energy X-ray Absorptiometry)

OTHERStandard intervention

Standard intervention

Locations(1)

Service Endocrinologie, Hôpital St Antoine

Paris, France

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NCT07412028

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