Studying the Role of Circulating Tumor Cell Clusters in Patients With High-risk Early Breast Cancer, Study GALIA

This study examines whether clusters of tumor cells circulating in the blood (called circulating tumor cell clusters, or CTCs) can predict outcomes in people with high-risk early breast cancer, including inflammatory breast cancer and triple-negative or HER2-positive subtypes. **You may be eligible if...** - You have inflammatory breast cancer (any subtype, stage IIID) - You have non-inflammatory triple-negative or HER2-positive breast cancer from stage IIB to IIIA-C - You are healthy enough to receive neoadjuvant (pre-surgery) systemic treatment **You may NOT be eligible if...** - You have a different breast cancer subtype or stage - Your health does not allow systemic therapy Talk to your doctor to see if this trial is right for you.