RecruitingNCT07418242

Prognostic Value of Novel Biomarkers on Adverse Renal Outcomes in High-Risk Cardiac Surgery Patients

Prognostic Value of Novel Biomarker on Adverse Renal Outcomes in High-Risk Cardiac Surgery Patients

Sponsor

Guowei Tu

Enrollment

1,491 participants

Start Date

Feb 23, 2026

Study Type

OBSERVATIONAL

Conditions

Cardiac Surgery associated Acute kidney injury Critical Illness

Summary

This project aims to detect novel biomarkers from preoperative and early postoperative serum and urine samples of patients to screen and analyze the risk factors for predicting adverse postoperative renal outcomes in high-risk patients in cardiac surgery.

Eligibility

Min Age: 18 YearsMax Age: 90 Years

Inclusion Criteria10

The AKI risk factors were as follows:
age >70 years;
< estimated glomerular filtration rate (eGFR) <60 mL·min-1·1.73 m-2;
diabetes mellitus, proteinuria;
a history of congestive heart failure within the previous year;
a left ventricular ejection fraction of 40% or lower;
prior cardiac surgery;
combined coronary artery bypass/valve procedure;
urgent procedure;
preoperative intra-aortic balloon pump.

Exclusion Criteria7

pre-existing chronic kidney disease (preoperative estimated glomerular filtration rate \[eGFR\] < 30 mL/min/1.73 m2);
previous RRT before cardiac surgery;
present AKI at screening;
a history of kidney transplant or other kidney diseases;
known pregnancy;
multiple operation during the hospital stay;
being in a moribund state (with an anticipated likelihood of death within 48 hours).

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Interventions

OTHERStandard care "bundle"

The management for AKI patients were performed by implementing a standard care "bundle" suggested by the Kidney Disease Improving Global Outcome (KDIGO) guideline.