RecruitingPhase 4NCT07420127

Comparison of Two Different Doses of Phenylephrine on Oxytocin Hemodynamic Effect

Effects of Two Different Doses of Phenylephrine co Administration on Oxytocin- Induced Hemodynamic Effects

Sponsor

Rawalpindi Medical College

Enrollment

112 participants

Start Date

Feb 13, 2026

Study Type

INTERVENTIONAL

Conditions

Phenylephrine Cesarean Birth

Summary

Cesarean section is one of the commonly performed surgical procedures in the world. Once baby is delivered during the surgical procedure anesthesiologist administer Oxytocin drug through IV cannula which helps the Uterus to contract so that excessive blood loss doesnt occur. But this is associated with fall in blood pressure frequently requiring administration of medications to treat low blood pressure. The most frequently used drug is phenylephrine which can administered along with oxytocin to prevent fall in blood pressure. This study will compare to different doses of Phenylephrine to prevent fall in blood pressure.

Eligibility

Sex: FEMALEMin Age: 20 YearsMax Age: 40 Years

Plain Language Summary

Simplified for easier understanding

This study compares two different doses of a blood pressure medication called phenylephrine to prevent a dangerous drop in blood pressure caused by the drug oxytocin, which is given during cesarean section (C-section) to help the uterus contract after delivery. **You may be eligible if...** - You are pregnant with a single baby - You are scheduled for a planned (elective) C-section under spinal anesthesia **You may NOT be eligible if...** - You have an abnormal placenta - You take beta-blockers or vasodilator medications - You have a hypertensive disorder of pregnancy Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGPhenylephrine bolus 75 micrograms

After delivery of Baby during C section, patient will be administered 3 IU of Oxytocin over 3 minutes along with 75 micrograms of Phenylephrine Intravenously.

DRUGPhenylephrine bolus 50 micrograms

After delivery of Baby during C section, patient will be administered 3 IU of Oxytocin over 3 minutes along with 50 micrograms of Phenylephrine Intravenously.

Locations(1)

Department of Anesthesia, Holy Family Hospital, Rawalpindi

Rawalpindi, Punjab Province, Pakistan

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NCT07420127

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