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RecruitingPhase 4NCT07426458

Ventilation and Perfusion in Asthmatics

Ventilation and Perfusion in Individuals With Asthma

Sponsor

University of Miami

Enrollment

40 participants

Start Date

Apr 27, 2026

Study Type

INTERVENTIONAL

Conditions

Asthma

Summary

Assess regional changes to perfusion and ventilation from inhaled corticosteroid (ICS) and Fast-acting beta-antagonist (FABA) among adult asthmatics using radiographically derived estimates of regional ventilation (V-distribution), ventilation defect percentage (VDP), and ventilation heterogeneity (VH).

Eligibility

Min Age: 18 YearsMax Age: 75 Years

Inclusion Criteria4

  • Physician diagnosis of asthma
  • Baseline Forced Expiratory Volume in 1 Second (FEV1) < 80% of predicted, with reversibility (10%) on post-bronchodilator spirometry
  • Adults, 18-75 years of age
  • Long-term inhaled controller medication consisting of or including an Inhaled corticosteroids (ICS) at a steady dose for at least 3 months before enrollment

Exclusion Criteria8

  • Current cigarette smoking or a past history of >10 pack-year smoking
  • Current nicotine vaping
  • Pregnant and breast-feeding women
  • Respiratory infection within 4 weeks of proposed study date
  • Forced Expiratory Volume in 1 Second (FEV1) < 50%
  • Inhaled corticosteroids (ICS)/fast-acting beta agonist (FABA) intolerance
  • Use of beta-blockers
  • Use of systemic glucocorticosteroids or oral methyl-xanthines within 30 days of planned study visit.

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Interventions

DRUGAlbuterol Sulfate

Visit 1: Albuterol Sulfate (90mcg) two puffs will be administered via metered-dose inhaler (MDI) with spacer during the baseline study visit to obtain baseline imaging values.

DRUGAlbuterol-Budesonide

Visit 2: AIRSUPRA (Albuterol/Budesonide) (90mcg/80mcg) two puffs will be administered via MDI with spacer during this study visit. This intervention is used to evaluate its effect on ventilation defect percentage (VDP), ventilation heterogeneity (VH), and perfusion metrics derived from XV LVAS imaging

Locations(1)

University of Miami - Converge Miami

Miami, Florida, United States

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NCT07426458

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