RecruitingNot ApplicableNCT07430007

Exercise and Dietary Lifestyle Intervention on Reducing Atrial Fibrillation Burden, Cardiac and Body Fat Mass.

Effect of a Tailored Exercise and Dietary Lifestyle Intervention on Reducing Atrial Fibrillation Burden, Cardiac and Body Fat Mass in Overweight and Obese Patients. The MOVE-AF Ran-domized Clinical Trial

Sponsor

University of Eastern Finland

Enrollment

158 participants

Start Date

Oct 30, 2025

Study Type

INTERVENTIONAL

Conditions

Atrial Fibrillation (AF)

Summary

Atrial fibrillation (AF) is the most common cardiac arrhythmia and is strongly associated with obesity and excess body fat. Lifestyle interventions, including exercise and dietary modification, may reduce AF burden, but long-term randomized controlled trial evidence with objective AF burden assessment and advanced cardiac imaging is limited. The MOVE-AF trial is a randomized controlled trial designed to evaluate whether a 12-month tailored exercise and dietary lifestyle intervention, compared with usual care, reduces atrial fibrillation burden and symptom severity and decreases cardiac and total body fat mass in overweight and obese adults with paroxysmal or persistent AF.

Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a structured exercise and dietary lifestyle program can reduce the burden of atrial fibrillation (an irregular heartbeat) and help decrease fat around the heart and in the body. Being overweight and inactive are known to worsen atrial fibrillation, and this trial aims to see whether lifestyle change alone can make a meaningful difference. **You may be eligible if...** - You are between 18 and 75 years old - You have a BMI of 27 kg/m² or higher - You have documented atrial fibrillation (paroxysmal — comes and goes — or persistent) - You are able to exercise and follow the study program - You have access to a smartphone or device for heart rhythm monitoring **You may NOT be eligible if...** - Your atrial fibrillation is permanent - You have had unstable chest pain or a heart attack in the past 3 months - You have severe heart failure, severe valve disease, or planned cardiac surgery - You are already participating in another weight loss or lifestyle trial - You have severe lung disease Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALTailored Exercise and Dietary Lifestyle Program

A 12-month tailored lifestyle program combining individualized aerobic exercise, muscle strength training, and dietary counseling. The program includes home-based aerobic training 2-5 times per week, muscle strength training, group-based dietary intervention sessions, and motivational support. The intervention is added to standard clinical care for atrial fibrillation.

OTHERUsual Clinical Care

Participants receive standard clinical care for atrial fibrillation according to the guideline-based routine practice at participating hospitals. No structured exercise or dietary lifestyle intervention is provided.