RecruitingPhase 4NCT07435337

Effect of Nalbuphine Versus Fentanyl on Hemdoynamic Effects of Laryngoscopy

COMPARISON OF HEMODYNAMIC EFFECTS OF NALBUPHINE VERSUS FENTANYL: A RANDOMIZED, DOUBLE-BLINDED INTERVENTIONAL STUDY IN PATIENTS ON CARDIOPULMONARY BYPASS AT RAWALPINDI INSTITUTE OF CARDIOLOGY, RAWALPINDI


Sponsor

Rawalpindi Institute of Cardiology

Enrollment

98 participants

Start Date

Feb 21, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

Participants will undergo routine pre-operative evaluation. An intravenous line will be placed in the recovery area. On arrival in the operating room, standard monitoring (blood pressure, heart rate, oxygen saturation, ECG, breathing monitor, and temperature) will be applied. A central venous catheter and an arterial line will be inserted under local anesthesia using sterile technique. Before anesthesia induction, patients will receive premedication including midazolam and an opioid pain-relief injection given slowly through the vein. General anesthesia will then be induced with etomidate. After adequate sedation, a muscle relaxant (atracurium) will be administered, and the patient will be ventilated with 100% oxygen using a face mask. The breathing tube will then be inserted and correct placement confirmed. During surgery, anesthesia will be maintained with oxygen, sevoflurane gas, and a continuous atracurium infusion. Hemodynamic parameters such as heart rate and blood pressure will be monitored throughout the peri-intubation and intraoperative period.


Eligibility

Min Age: 40 YearsMax Age: 60 Years

Inclusion Criteria3

  • Weighing 40-70kg
  • ASA III of either sex
  • Undergoing cardiac surgery with CPB

Exclusion Criteria1

  • • History of Drug Allergy • Pre-existing Asthma • Renal or Hepatic dysfunction • Extreme obesity • Pregnant / lactating patients • Difficult intubation/prolonged intubation

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Interventions

DRUGNalbuphine

IV Nalbuphine at dose of 0.2 mg/kg will be given 5 minutes before induction of anesthesia

DRUGFentanyl

3 Microgram per kilogram body weight IV Fentanyl will be given 5 minutes before induction of anesthesia


Locations(1)

Deparment of Anesthesia, Rawalpindi Institute of Cardiology, Rawalpindi

Rawalpindi, Punjab Province, Pakistan

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NCT07435337


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