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RecruitingNCT07435935

Bone Myoregulation Reflex and Postural Control in Vitamin D Deficiency

Investigation of Postural Stability and Load-Sensitive Neuromuscular Control Mechanisms in Vitamin D Deficiency

Sponsor

Istanbul Physical Medicine Rehabilitation Training and Research Hospital

Enrollment

24 participants

Start Date

Mar 5, 2026

Study Type

OBSERVATIONAL

Conditions

Vitamin D Deficiency

Summary

This observational study aims to investigate the relationship between vitamin D deficiency, postural stability, and neuromuscular control mechanisms in adults. The study will compare individuals with vitamin D deficiency and healthy controls. Participants will undergo a single-session evaluation including surface electromyography and postural stability assessments during standing tasks under different loading and vibration conditions. No invasive procedures, medications, or blood sampling will be performed. Previously obtained routine laboratory results will be used for vitamin D status. The study is designed to improve understanding of neuromuscular responses associated with vitamin D deficiency and to contribute to future rehabilitation strategies.

Eligibility

Min Age: 20 YearsMax Age: 40 Years

Inclusion Criteria5

  • Age 20 to 40 years.
  • Ability to provide written informed consent.
  • Vitamin D deficiency group: serum 25-hydroxyvitamin D level <10 ng/mL measured within the last 3 months (routine clinical testing).
  • Healthy control group: normal vitamin D status based on routine clinical testing within the last 3 months.
  • No use of vitamin D or calcium supplementation within the last 3 months.

Exclusion Criteria8

  • Known metabolic bone disease other than vitamin D deficiency.
  • Neurological disorder (central or peripheral) or neuromuscular disease.
  • History of lower-limb surgery, fracture, or prosthesis affecting standing balance.
  • Vestibular disorder.
  • BMI >30 kg/m2.
  • Active malignancy.
  • Severe psychiatric disorder.
  • Skin condition preventing placement of surface EMG electrodes.

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Locations(1)

Istanbul Physical Medicine and Rehabilitation Training and Research Hospital

Istanbul, Turkey (Türkiye)

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NCT07435935

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