RecruitingNot ApplicableNCT07436351

ACT With CF Self-Help Toolkit

Sponsor

Thomas Jefferson University

Enrollment

60 participants

Start Date

Jan 20, 2026

Study Type

INTERVENTIONAL

Conditions

Cystic Fibrosis (CF)Psychological Flexibility Depressive and Anxiety Disorders

Summary

Acceptance and Commitment Therapy (ACT) tailored to meet the needs of adults living with cystic fibrosis (ACT with CF) is a newer form of talk therapy that has been shown to reduce anxiety \& depression and improve psychological flexibility, and value-based living. The investigators are now trying to find out whether a self-help version of this treatment (ACT with CF - Self Help Toolkit) is also effective in reducing anxiety and depression and improving psychological flexibility and value-based living in adults with CF. Adults with cystic fibrosis are at increased risk for anxiety and depression. This study examines whether a patient-facing therapy, ACT with CF - Self Help Toolkit can help to reduce anxiety and depression among adults with CF. This treatment can be accessed on the participant's smartphone.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study tests a self-help toolkit based on Acceptance and Commitment Therapy (ACT) — a type of psychological approach that helps people manage difficult thoughts and emotions — for people with cystic fibrosis who are experiencing anxiety or depression. **You may be eligible if...** - You are 18 or older - You have a confirmed diagnosis of cystic fibrosis - You are experiencing mild to moderate anxiety or depression (scoring above 4 on either the PHQ-9 or GAD-7 questionnaires) **You may NOT be eligible if...** - You have a history of suicide attempts or are currently having thoughts of suicide - You have a psychotic disorder or symptoms - You have another psychiatric condition that would interfere with the study - You have a condition that your clinician feels makes participation unsuitable Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALACT with CF Self-Help Toolkit

The ACT with CF Self-Help Toolkit will include 6 main modules, each with 3 or 4 kernels, which will be short videos, in which participants will learn new ways to manage uncomfortable experiences and feelings (e.g., anxiety, depression) and to engage in positive behaviors. These videos are based on the main interventions in our ACT with CF individual therapy protocol. For example, the first main module focuses on how the participant wants to live their life (Values Clarification Intervention), and the kernels in this module are 1-3 minute video clips demonstrating different ways to figure this out (Card Sort, 70th Birthday exercise, accessing barriers). This intervention is directly adapted from the ACT with CF manual, which has been studied previously in several forms and studies.

OTHERWaitlist

Participants in the waitlist condition will wait for six weeks before receiving the ACT with CF Self-Help Toolkit